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Review

The Mitochondrial Dysfunction Hypothesis in Autism Spectrum Disorders: Current Status and Future Perspectives

by
Luigi Citrigno
1,†,
Maria Muglia
1,†,
Antonio Qualtieri
1,
Patrizia Spadafora
1,
Francesca Cavalcanti
1,
Giovanni Pioggia
2 and
Antonio Cerasa
1,3,*
1
Institute for Biomedical Research and Innovation, National Research Council, IRIB-CNR, 87050 Mangone CS, Italy
2
Institute for Biomedical Research and Innovation, National Research Council, IRIB-CNR, 98164 Messina, Italy
3
S’Anna Institute and Research in Advanced Neurorehabilitation (RAN), 88100 Crotone, Italy
*
Author to whom correspondence should be addressed.
†
These Authors equally contributed to this word.
Int. J. Mol. Sci. 2020, 21(16), 5785; https://doi.org/10.3390/ijms21165785
Submission received: 15 June 2020 / Revised: 28 July 2020 / Accepted: 4 August 2020 / Published: 12 August 2020
(This article belongs to the Collection Feature Papers in Molecular Genetics and Genomics)
Review Reports Versions Notes

Abstract

Autism spectrum disorders (ASDs) constitute a set of heterogeneous neurodevelopmental conditions, characterized by a wide genetic variability that has led to hypothesize a polygenic origin. The metabolic profiles of patients with ASD suggest a possible implication of mitochondrial pathways. Although different physiological and biochemical studies reported deficits in mitochondrial oxidative phosphorylation in subjects with ASD, the role of mitochondrial DNA variations has remained relatively unexplored. In this review, we report and discuss very recent evidence to demonstrate the key role of mitochondrial disorders in the development of ASD.
Keywords: autism spectrum disorder (ASD); mitochondrial DNA (mtDNA); mitochondrial dysfunctions; next generation sequencing (NGS) autism spectrum disorder (ASD); mitochondrial DNA (mtDNA); mitochondrial dysfunctions; next generation sequencing (NGS)

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MDPI and ACS Style

Citrigno, L.; Muglia, M.; Qualtieri, A.; Spadafora, P.; Cavalcanti, F.; Pioggia, G.; Cerasa, A. The Mitochondrial Dysfunction Hypothesis in Autism Spectrum Disorders: Current Status and Future Perspectives. Int. J. Mol. Sci. 2020, 21, 5785. https://doi.org/10.3390/ijms21165785

AMA Style

Citrigno L, Muglia M, Qualtieri A, Spadafora P, Cavalcanti F, Pioggia G, Cerasa A. The Mitochondrial Dysfunction Hypothesis in Autism Spectrum Disorders: Current Status and Future Perspectives. International Journal of Molecular Sciences. 2020; 21(16):5785. https://doi.org/10.3390/ijms21165785

Chicago/Turabian Style

Citrigno, Luigi, Maria Muglia, Antonio Qualtieri, Patrizia Spadafora, Francesca Cavalcanti, Giovanni Pioggia, and Antonio Cerasa. 2020. "The Mitochondrial Dysfunction Hypothesis in Autism Spectrum Disorders: Current Status and Future Perspectives" International Journal of Molecular Sciences 21, no. 16: 5785. https://doi.org/10.3390/ijms21165785

APA Style

Citrigno, L., Muglia, M., Qualtieri, A., Spadafora, P., Cavalcanti, F., Pioggia, G., & Cerasa, A. (2020). The Mitochondrial Dysfunction Hypothesis in Autism Spectrum Disorders: Current Status and Future Perspectives. International Journal of Molecular Sciences, 21(16), 5785. https://doi.org/10.3390/ijms21165785

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