The Effect of Low Temperatures on Environmental Radiation Damage in Living Systems: Does Hypothermia Show Promise for Space Travel?
Abstract
:1. Introduction
2. Environmental Radiation Damage in Living Systems
3. Mechanisms of the Effect of Hypothermia-Induced Radioprotection
4. Impairment of Radiation Damage Repair under Hypothermic Conditions
5. Possible Issues Related to Human Space Exploration and the Induction of Hibernation
6. Conclusions
Funding
Conflicts of Interest
Abbreviations
IR | Ionizing radiation |
IARC | International Agency for Research on Cancer |
UV | Ultraviolet radiation |
ICRP | International Commission on Radiological Protection |
SI | International System of Units |
Gy | Gray |
Sv | Sievert |
LET | Linear energy transfer |
RIBE | Radiation induced bystander effect |
SCE | Sister chromatid exchanges |
TSE | Tissue-sparing effect |
MRT | Microbeam radiotherapy |
ROS | Reactive oxygen species |
HIF | Hypoxia inducible factor |
CIRP | Cold-inducible RNA binding protein |
UNSCEAR | United Nations Scientific Committee on the Effects of Atomic Radiation |
LEO | Low-Earth orbit |
HZE | High atomic number and energy |
GCR | Galactic cosmic ray |
NASA | National Aeronautics and Space Administration |
MPS | Million Person Study of Low-Dose Health Effects |
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Fukunaga, H. The Effect of Low Temperatures on Environmental Radiation Damage in Living Systems: Does Hypothermia Show Promise for Space Travel? Int. J. Mol. Sci. 2020, 21, 6349. https://doi.org/10.3390/ijms21176349
Fukunaga H. The Effect of Low Temperatures on Environmental Radiation Damage in Living Systems: Does Hypothermia Show Promise for Space Travel? International Journal of Molecular Sciences. 2020; 21(17):6349. https://doi.org/10.3390/ijms21176349
Chicago/Turabian StyleFukunaga, Hisanori. 2020. "The Effect of Low Temperatures on Environmental Radiation Damage in Living Systems: Does Hypothermia Show Promise for Space Travel?" International Journal of Molecular Sciences 21, no. 17: 6349. https://doi.org/10.3390/ijms21176349