Mitochondrial Surveillance by Cdc48/p97: MAD vs. Membrane Fusion
Abstract
:1. Introduction
2. The Molecular Mechanism of Cdc48/p97
3. Cdc48/p97 in Mitochondrial-Associated Degradation (MAD) and Respective Quality Control Roles
3.1. Ubx2- and Cdc48-Dependent MAD during Mitochondrial Import
3.2. Ufd3/Doa1 and Msp1 in Surveillance of Proteins Present at the OMM
3.3. Roles of Vms1 in Oxidative Stress and Ribosomal Quality Control
3.4. Pro- and Antiapoptotic Roles of Cdc48 in Mitochondria
3.5. Regulation of Mitophagy by Cdc48/p97-MAD of Mitofusins
4. Beyond MAD: Regulation of the Mitofusins’ Fusion Activity by Cdc48
4.1. Mechanism Governing OMM Fusion
4.2. Roles of Ubiquitin and Cdc48 in OMM Fusion
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Escobar-Henriques, M.; Anton, V. Mitochondrial Surveillance by Cdc48/p97: MAD vs. Membrane Fusion. Int. J. Mol. Sci. 2020, 21, 6841. https://doi.org/10.3390/ijms21186841
Escobar-Henriques M, Anton V. Mitochondrial Surveillance by Cdc48/p97: MAD vs. Membrane Fusion. International Journal of Molecular Sciences. 2020; 21(18):6841. https://doi.org/10.3390/ijms21186841
Chicago/Turabian StyleEscobar-Henriques, Mafalda, and Vincent Anton. 2020. "Mitochondrial Surveillance by Cdc48/p97: MAD vs. Membrane Fusion" International Journal of Molecular Sciences 21, no. 18: 6841. https://doi.org/10.3390/ijms21186841