Next Article in Journal
Optimization for Liquid-Liquid Extraction of Cd(II) over Cu(II) Ions from Aqueous Solutions Using Ionic Liquid Aliquat 336 with Tributyl Phosphate
Next Article in Special Issue
Inhibition of the FGF/FGFR System Induces Apoptosis in Lung Cancer Cells via c-Myc Downregulation and Oxidative Stress
Previous Article in Journal
Characterization of Variable Region Genes and Discovery of Key Recognition Sites in the Complementarity Determining Regions of the Anti-Thiacloprid Monoclonal Antibody
Previous Article in Special Issue
Cell Density-Dependent Fibroblast Growth Factor-2 Signaling Regulates Syndecan-4 Expression in Cultured Vascular Endothelial Cells
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 21
Issue 18
10.3390/ijms21186856
Review Report
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Review
Peer-Review Record

FGFR Fusions in Cancer: From Diagnostic Approaches to Therapeutic Intervention

Int. J. Mol. Sci. 2020, 21(18), 6856; https://doi.org/10.3390/ijms21186856
by Antonella De Luca 1, Riziero Esposito Abate 1, Anna Maria Rachiglio 1, Monica Rosaria Maiello 1, Claudia Esposito 1, Clorinda Schettino 2, Francesco Izzo 3, Guglielmo Nasti 4 and Nicola Normanno 1,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2020, 21(18), 6856; https://doi.org/10.3390/ijms21186856
Submission received: 31 July 2020 / Revised: 15 September 2020 / Accepted: 15 September 2020 / Published: 18 September 2020
(This article belongs to the Special Issue FGF/FGFR Signaling Pathway in Development and Human Diseases)

Round 1

Reviewer 1 Report

- explain OS on line 282

- explain PFS on line 317

- move "disease control rate" from line 350 to line 317

Author Response

Please see the attachment

Author Response File: Author Response.pdf

Reviewer 2 Report

In this review, the authors want to describe FGFR aberrations in human cancer. By focusing on FGFR fusion proteins and the potential role of these aberrations as prognostic markers.
The topics are very well developed and treated in an orderly and organic way.
However, I would advise the authors to give more weight to a much discussed topic in recent years, namely the impact of aberrant splicing of the various FGFR isoforms which has been seen to have important effects on tumorigenesis. For example, there are papers indicating aberrant splicing induced by oncovirus proteins that drive towards EMT. Or there are oncogenic effects of aberrant splicing even in normal cellular contexts, Etc. All to underline that fusion proteins can also have an impact on the splicing of FGFR isoforms and therefore on tumor evolution and development.

Author Response

Please see the attachment

Author Response File: Author Response.pdf

Back to TopTop