Immunological Memory of Psoriatic Lesions
Abstract
:1. Introduction
2. Tissue Resident Memory Cells (TRM)
3. Tissue Resident Memory Cells in Psoriasis
4. Tissue Resident Memory Cells in Psoriatic Arthritis (PsA)
5. The Role of Memory γδ T Cells
6. Th22 and Tc17 Lymphocytes
7. Epidermal Langerhans Cells (LCs)
8. Clinical Significance of the Memory of Psoriasis Lesions
9. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Type of Cells | Psoriasis Lesions | Resolved Psoriasis Skin | |
---|---|---|---|
TRM | CD4+ | A few in dermis CD103- and a low number in epidermis CD103+ | A few |
CD8+ | A lot of in epidermis CD103+: CD8+CD49a+ producing perforin, IFN-γ CD8+CD49a- producing IL-17 IL-22, IFN-γ, a few in dermis CD103- and a low number CD103+ | A few in epidermis | |
Dendritic Cells | LC | In epidermis producing a lot of IL-23 | In epidermis producing IL-23 |
eDC | In epidermis producing of IL-1β, IL-23, TNFα | Absent |
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Owczarczyk-Saczonek, A.; Krajewska-Włodarczyk, M.; Kasprowicz-Furmańczyk, M.; Placek, W. Immunological Memory of Psoriatic Lesions. Int. J. Mol. Sci. 2020, 21, 625. https://doi.org/10.3390/ijms21020625
Owczarczyk-Saczonek A, Krajewska-Włodarczyk M, Kasprowicz-Furmańczyk M, Placek W. Immunological Memory of Psoriatic Lesions. International Journal of Molecular Sciences. 2020; 21(2):625. https://doi.org/10.3390/ijms21020625
Chicago/Turabian StyleOwczarczyk-Saczonek, Agnieszka, Magdalena Krajewska-Włodarczyk, Marta Kasprowicz-Furmańczyk, and Waldemar Placek. 2020. "Immunological Memory of Psoriatic Lesions" International Journal of Molecular Sciences 21, no. 2: 625. https://doi.org/10.3390/ijms21020625