Altered Tumor Plasticity after Different Cancer Cell Fusions with MSC
Abstract
:1. Introduction
2. MSC Functionality and Tumor Interactions
3. MSC and Cancer Cell Fusion
3.1. Different Hybrid Cancer Cell Lines Following Fusion with MSC
3.2. Enhanced and Reduced Tumorigenicity of Hybrid Cancer Cell Lines after Fusion with MSC
3.3. Potential Cancer Stem Cell-Like Properties in Hybrid Cancer Cell Populations
4. Mechanisms of Cancer Cell Fusion
4.1. Molecular Signals Involved in Physiological Cell Fusion
4.2. Signaling Events Contributing to Pathophysiological Cell Fusion
5. Post-Fusion or Post-Hybrid Selection Processes (PHSPs)
6. Summary
Author Contributions
Funding
Conflicts of Interest
Abbreviations
ASCT-2 | alanine: serine, and cysteine selective transporter-2 |
GFP | green fluorescent protein |
HST | hetero-to-synkaryon transition |
hTERT | human telomerase reverse transcriptase |
MDA-hyb1 to -hyb5 | MDA-MSC-hyb1 to -hyb5 (hybrid cells after fusion of MDA-MB-231 with MSC) |
MFSD-2A | major facilitator superfamily domain containing 2A |
MSC | mesenchymal stroma/stem-like cells |
PHSP | post-hybrid selection process |
TNF-α | tumor necrosis factor-alpha |
TRADD | TNFR1-associated death domain protein |
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Cancer Cell Line Fusion Partner | hUC-MSC Fusion Partner | Hybrid Cancer Cell Line | mRNA Microarray Data | References |
---|---|---|---|---|
MDA-MB-231 | MSC051212 | MDA-MSC-hyb1 | GSE100551 | [34] |
MDA-MB-231 | MSC051212 | MDA-MSC-hyb2 | GSE100551 | [34] |
MDA-MB-231 | MSC290115 | MDA-MSC-hyb3 | n.d. | [36] |
MDA-MB-231 | MSC290115 | MDA-MSC-hyb4 | n.d. | [36] |
MDA-MB-231 | MSC030816 | MDA-MSC-hyb5 | GSE157199 | |
SK-OV-3 | MSC081113 | SK-MSC-hyb1 | GSE117411 | [37] |
SK-OV-3 | MSC081113 | SK-MSC-hyb2 | GSE117411 | [37] |
MCF10A | MSC060616 | MCF10A-MSC-hyb1 | GSE106756 | [35] |
MCF10A | MSC060616 | MCF10A-MSC-hyb2 | GSE106756 | [35] |
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Melzer, C.; Ohe, J.v.d.; Hass, R. Altered Tumor Plasticity after Different Cancer Cell Fusions with MSC. Int. J. Mol. Sci. 2020, 21, 8347. https://doi.org/10.3390/ijms21218347
Melzer C, Ohe Jvd, Hass R. Altered Tumor Plasticity after Different Cancer Cell Fusions with MSC. International Journal of Molecular Sciences. 2020; 21(21):8347. https://doi.org/10.3390/ijms21218347
Chicago/Turabian StyleMelzer, Catharina, Juliane von der Ohe, and Ralf Hass. 2020. "Altered Tumor Plasticity after Different Cancer Cell Fusions with MSC" International Journal of Molecular Sciences 21, no. 21: 8347. https://doi.org/10.3390/ijms21218347