Mechanistic Insights into the Role of Molecular Chaperones in Protein Misfolding Diseases: From Molecular Recognition to Amyloid Disassembly
Abstract
:1. Introduction
2. Dynamic Hsp70 and Hsp90 Are Closely Monitored by Co-Chaperones
3. Selective Recognition of Misfolded Proteins by Hsp70 and Hsp90
4. Hsp70 and Hsp90 Play Crucial Roles in Disease-Related LLPS
5. Pathological vs. Functional Amyloids
- (i)
- Scaffolding systems, such as curli in microbial biofilm, providing a scaffold to protect bacteria and promote adherence to host cells [128].
- (ii)
- Storage systems, such as Pmel17, which allows for the sequestration and condensation of melanin in the lumen of melanosomes [129]; vicilin, a 7S globulin in garden pea Pisum sativum L. seeds, which plays a crucial role in seed longevity [130]; peptide hormones for storage and release of certain hormones in the pituitary secretory granules [8]; Xvelo in Xenopus or Bucky Ball in zebrafish, which form a non-membranous compartment termed the Balbiani body to store germline-specific maternal mRNAs [131].
- (iii)
- (iv)
- Translation regulator systems, such as the yeast prion [PSI+], a general translational terminator that provides heritable phenotypic variability [134]; Rim4, a translation inhibitor of cyclin mRNA that controls gametogenesis [135]; or Orb2, the Drosophila member of the mRNA-binding cytoplasmic polyadenylation element family of proteins [136,137].
- (v)
- Enzymatic systems, such as the membrane-associated protein Herzog (Hzg), which is required for the proper establishment of segment polarity in Drosophila embryo through an amyloid-like assembly that activates a phosphatase that is crucial for proper development [138].
6. Interplay between Chaperones and Amyloids
7. Aberrant Chaperone Complexes Have Deleterious Consequences
8. Concluding Remarks
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
PN | Proteostasis network |
LLPS | Liquid–liquid phase separation |
Hsp | Heat-shock protein |
sHsp | Small Hsp |
NBD | Nucleotide-binding domain (Hsp70) |
SBD | Substrate-binding domain (Hsp70) |
TPR | Tetratricopeptide repeat |
Hop | Hsp-organizing protein |
NTD | N-terminal domain (Hsp90) |
MD | Middle domain (Hsp90) |
CTD | C-terminal domain (Hsp90) |
NEF | Nucleotide exchange factor |
ATP | Adenosine triphosphate |
TTR | Transthyretin |
SOD1 | Superoxide dismutase 1 |
ALS | Amyotrophic lateral sclerosis |
IDP | Intrinsically disordered protein |
HTT | Huntingtin |
IAPP | Islet amyloid polypeptide |
TDP-43 | TAR DNA binding protein of 43 kDa |
NMR | Nuclear magnetic resonance |
Aβ | Amyloid-β |
RNP | Ribonucleoprotein particle |
SG | Stress granule |
Hzg | Herzog |
NMNAT | Nicotinamide mononucleotide adenylyl transferase |
PPIase | Peptidyl-proline isomerase |
USP19 | Ubiquitin-specific protease 19 |
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Hervás, R.; Oroz, J. Mechanistic Insights into the Role of Molecular Chaperones in Protein Misfolding Diseases: From Molecular Recognition to Amyloid Disassembly. Int. J. Mol. Sci. 2020, 21, 9186. https://doi.org/10.3390/ijms21239186
Hervás R, Oroz J. Mechanistic Insights into the Role of Molecular Chaperones in Protein Misfolding Diseases: From Molecular Recognition to Amyloid Disassembly. International Journal of Molecular Sciences. 2020; 21(23):9186. https://doi.org/10.3390/ijms21239186
Chicago/Turabian StyleHervás, Rubén, and Javier Oroz. 2020. "Mechanistic Insights into the Role of Molecular Chaperones in Protein Misfolding Diseases: From Molecular Recognition to Amyloid Disassembly" International Journal of Molecular Sciences 21, no. 23: 9186. https://doi.org/10.3390/ijms21239186
APA StyleHervás, R., & Oroz, J. (2020). Mechanistic Insights into the Role of Molecular Chaperones in Protein Misfolding Diseases: From Molecular Recognition to Amyloid Disassembly. International Journal of Molecular Sciences, 21(23), 9186. https://doi.org/10.3390/ijms21239186