UBAC1/KPC2 Regulates TLR3 Signaling in Human Keratinocytes through Functional Interaction with the CARD14/CARMA2sh-TANK Complex
, Michele Congestrì 2, Ivan Scudiero 1, Immacolata Polvere 2,3, Serena Voccola 3, Lucrezia Zerillo 3, Gianluca Telesio 1, Pasquale Vito 2,3,*, Romania Stilo 2 and Tiziana Zotti 2,3Round 1
Reviewer 1 Report
Nice study. Well performed and presented.It is a very well designed work, with materials and methods that allow the results to be perfectly understood The discussion and conclusion are consistent with the results. This is a very new job.
Author Response
Dear Editor,
We thank the reviewer for appreciating the manuscript.
Reviewer 2 Report
In the manuscript entitled "UBAC1/KPC2 regulates TLR3 signaling in human keratinocytes through functional interaction with the CARD14/CARMA2sh-TANK complex", the authors have found the UBA Domain Containing 1 (UBAC1) as an interactor of CARMA2sh in human keratinocytes. The topic is interesting and the data is convicing.
There is only one point, it would be better if it could be improved. The statistical data of repeated experiments could be shown for the blots.
Author Response
Dear Editor,
We thank the reviewer for appreciating the manuscript.
The blot experiments shown in Fig. 1 are qualitative (the answer is yes/not). We added in the figure legend the statement that data shown is representative of three independent experiments.
The statistical data of repeated experiments for the blots shown in Fig. 3, which are quantitative, will be provided as supplementary material.
