The Current Status of Drug Repositioning and Vaccine Developments for the COVID-19 Pandemic
Abstract
:1. Introduction
2. Coronavirus in Brief
3. Drug Repositioning for SARS-CoV-2 Infection
3.1. Nucleoside Analogs
3.2. Protease Inhibitors
3.3. Chloroquine/Hydroxychloroquine
4. Vaccines for SARS-CoV-2 Prevention
4.1. Protein Subunit Vaccines
4.2. Viral-Vectored Vaccines
4.3. Nucleic Acid Vaccines (mRNA and DNA)
4.4. Others: Live Attenuated or Inactivated Vaccines
5. Remaining Challenges
6. Conclusion
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
COVID-19 | Coronavirus disease 2019 |
SARS-CoV-2 | Severe acute respiratory syndrome coronavirus 2 |
WHO | World health organization |
+ssRNA | Positive single-strand RNA virus |
MERS | Middle east respiratory syndrome |
ACE2 | Angiotensin-converting enzyme 2 |
RdRp | RNA-dependent RNA polymerase |
FDA | Food and Drug Administration |
EUA | Emergency use authorization |
GMP | Good manufacturing practice |
CEPI | Coalition for epidemic Preparedness Innovations |
EU | ELISA units |
NIAID | National institute of allergy and infectious diseases |
GMT | Geometric mean titers |
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Candidate | Target | Mechanisms | References |
---|---|---|---|
Remdesivir | RdRp | Interferes with virus RNA polymerases to inhibit virus replication. | [19] |
Ribavirin | RdRp | Inhibits nucleotide biosynthesis by inhibiting viral RNA polymerase. | [20] |
Favipiravir | RdRp | Inhibits viral transcription and replication. | [21,22] |
Lopinavir/Ritonavir | Viral main proteases | Inhibits the viral proteases and blocks the multiplication. | [23,24] |
Darunavir | Viral main proteases | Inhibits virus maturation by inhibiting the viral protease. | [25,26] |
Chloroquine/Hydroxychloroquine | Viral entry | Changes endosomal pH; Inhibits viral entry and interferes with RdRp function. | [27,28,29] |
Arbidol | Spike glycoprotein | Inhibits viral entry and post-entry stages. | [30,31] |
Platform | Developer | Vaccine Candidate | Status * |
---|---|---|---|
Protein subunit vaccine | Novavax | NVX-CoV-2373 | Phase 3 |
The University of Queensland | SARS-CoV-2 Sclamp | Abandoned | |
Clover Biopharmaceuticals | SCB-2019 | Phase 1 | |
Viral-vectored vaccine | Johnson & Johnson | Ad26.CoV2-S | Phase 3 |
AstraZeneca, University of Oxford | AZD1222 | Phase 2, Phase 3, Combined phases | |
Gamaleya Research Institute | Sputnik V | Phase 3, Early use in Russia | |
mRNA vaccine | Pfizer, BioNTech | BNT162b2 | Phase 2, Phase 3, Approved in Canada and other countries, Emergency use in U.S. |
Moderna, NIAID | mRNA-1273 | Phase 3, Under FDA review. | |
DNA vaccine | INOVIO Pharmaceuticals | INO-4800 | Phase 2 |
Genexine | GX-19 | Phase 1 | |
Inactivated Vaccine | Sinovac Biotech | CoronaVac | Phase 3, Limited use in China. |
The Chumakov Center at the Russian Academy of Sciences | Whole-virion vaccine | Phase 1, Phase 2, Combined phases |
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Won, J.-H.; Lee, H. The Current Status of Drug Repositioning and Vaccine Developments for the COVID-19 Pandemic. Int. J. Mol. Sci. 2020, 21, 9775. https://doi.org/10.3390/ijms21249775
Won J-H, Lee H. The Current Status of Drug Repositioning and Vaccine Developments for the COVID-19 Pandemic. International Journal of Molecular Sciences. 2020; 21(24):9775. https://doi.org/10.3390/ijms21249775
Chicago/Turabian StyleWon, Jung-Hyun, and Howard Lee. 2020. "The Current Status of Drug Repositioning and Vaccine Developments for the COVID-19 Pandemic" International Journal of Molecular Sciences 21, no. 24: 9775. https://doi.org/10.3390/ijms21249775