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Volume 21
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Review

Modulators of MicroRNA Function in the Immune System

by
Yunhui Jia
1 and
Yuanyuan Wei
2,*
1
Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China
2
Department of Immunology, Shanghai Key laboratory of Bioactive Small Molecules, State Key Laboratory of Medical Neurobiology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(7), 2357; https://doi.org/10.3390/ijms21072357
Submission received: 15 February 2020 / Revised: 23 March 2020 / Accepted: 27 March 2020 / Published: 29 March 2020
(This article belongs to the Special Issue New Regulators and Modulators of MicroRNA)
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Abstract

MicroRNAs (miRNAs) play a key role in fine-tuning host immune homeostasis and responses through the negative regulation of mRNA stability and translation. The pathways regulated by miRNAs are well characterized, but the precise mechanisms that control the miRNA-mediated regulation of gene expression during immune cell-development and immune responses to invading pathogens are incompletely understood. Context-specific interactions of miRNAs with other RNA species or proteins may modulate the function of a given miRNA. Dysregulation of miRNA function is associated with various human diseases, such as cardiovascular diseases and cancers. Here, we review the potential modulators of miRNA function in the immune system, including the transcription regulators of miRNA genes, miRNA-processing enzymes, factors affecting miRNA targeting, and intercellular communication.
Keywords: microRNA biogenesis; immune cells; miRNA site; exosome; macrophage microRNA biogenesis; immune cells; miRNA site; exosome; macrophage

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MDPI and ACS Style

Jia, Y.; Wei, Y. Modulators of MicroRNA Function in the Immune System. Int. J. Mol. Sci. 2020, 21, 2357. https://doi.org/10.3390/ijms21072357

AMA Style

Jia Y, Wei Y. Modulators of MicroRNA Function in the Immune System. International Journal of Molecular Sciences. 2020; 21(7):2357. https://doi.org/10.3390/ijms21072357

Chicago/Turabian Style

Jia, Yunhui, and Yuanyuan Wei. 2020. "Modulators of MicroRNA Function in the Immune System" International Journal of Molecular Sciences 21, no. 7: 2357. https://doi.org/10.3390/ijms21072357

APA Style

Jia, Y., & Wei, Y. (2020). Modulators of MicroRNA Function in the Immune System. International Journal of Molecular Sciences, 21(7), 2357. https://doi.org/10.3390/ijms21072357

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