Quantitative Assessment of Arthritis Activity in Rheumatoid Arthritis Patients Using [11C]DPA-713 Positron Emission Tomography
Abstract
:1. Introduction
2. Results
2.1. Clinical Data
2.2. Input Functions for Dynamic PET Data Analyses
2.3. Kinetic Analyses Using Non-linear Plasma Input Models
2.4. Linearized and Simplified Methods
2.5. SUV in Relation to Clinical Activity
3. Discussion
4. Materials and Methods
4.1. Patients
4.2. Clinical Assessment
4.3. Scanning Protocol
4.4. Image Segmentation
4.5. Kinetic Analysis Using Non-linear Plasma Input Models
4.6. Linearized and Simplified (Static) Analysis
4.7. Statistical Analysis
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Baseline Patient Demographics | |
---|---|
Male, number (%) | 1 (20) |
Age, years (mean ± SD) | 58 ± 5 |
Height, cm (mean ± SD) | 169 ± 15 |
Weight, kg (mean ± SD) | 82 ± 16 |
Disease duration, months (mean ± SD) | 314 ± 195 |
Anti-CCP positivity, number (%) | 3 (60) |
IgM RF positivity, number (%) | 3 (60) |
DAS 44 (mean ± SD) | 2.78 ± 0.43 |
44-swollen joint count (median ± IQR) | 7 ± 5 |
44-tender joint count (median ± IQR) | 6 ± 7 |
CRP, mg/mL (median ± IQR) | 3 ± 9 |
ESR, mm/h (median ± IQR) | 9 ± 27 |
VAS disease activity, 0 – 100 mm (mean ± SD) | 45 ± 19 |
DMARD therapy, number (%) | 3 (60) |
Oral prednisolone, number (%) | 4 (80) |
NSAID therapy, number (%) | 2 (40) |
Kinetic Parameter | Lower Bound | Upper Bound |
---|---|---|
K1 | 0.005 | 0.2 |
k2 | 0.01 | 0.5 |
k3 | 0.01 | 1.0 |
VT | 0.01 | 50 |
Vb | 0.001 | 1.0 |
Volume of Interest | 1T2k | 2T4k | 2T3k |
---|---|---|---|
Bone marrow | 0 | 0 | 100% |
Non-affected joint | 0 | 0 | 100% |
Affected joint | 0 | 28.6% | 71.4% |
Patient | Clinical Activity | Type of Joint | Arthritic Joint | Non-Affected, Contralateral Joint |
---|---|---|---|---|
1 | + | Knee | 3.6 | 2.4 |
2 | ++ | MCP2 | 10.2 | 4.0 |
3 | +++ | Knee | 16.5 | 2.4 |
4 | +++ | Knee | 12.4 | 8.1 |
5 | +++ | MTP1 | 12.7 | 2.0 |
Average | 11.1 | 3.8 |
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Yaqub, M.; Verweij, N.J.F.; Pieplenbosch, S.; Boellaard, R.; Lammertsma, A.A.; van der Laken, C.J. Quantitative Assessment of Arthritis Activity in Rheumatoid Arthritis Patients Using [11C]DPA-713 Positron Emission Tomography. Int. J. Mol. Sci. 2020, 21, 3137. https://doi.org/10.3390/ijms21093137
Yaqub M, Verweij NJF, Pieplenbosch S, Boellaard R, Lammertsma AA, van der Laken CJ. Quantitative Assessment of Arthritis Activity in Rheumatoid Arthritis Patients Using [11C]DPA-713 Positron Emission Tomography. International Journal of Molecular Sciences. 2020; 21(9):3137. https://doi.org/10.3390/ijms21093137
Chicago/Turabian StyleYaqub, Maqsood, Nicki J.F. Verweij, Simone Pieplenbosch, Ronald Boellaard, Adriaan A. Lammertsma, and Conny J. van der Laken. 2020. "Quantitative Assessment of Arthritis Activity in Rheumatoid Arthritis Patients Using [11C]DPA-713 Positron Emission Tomography" International Journal of Molecular Sciences 21, no. 9: 3137. https://doi.org/10.3390/ijms21093137