The Role of TNFR2 and DR3 in the In Vivo Expansion of Tregs in T Cell Depleting Transplantation Regimens
Abstract
:1. Introduction
1.1. The Role of Regulatory T Cells in Transplantation
1.2. T Cell Depletion in Peri-Transplant Regimens and Allogeneic Bone Marrow Transplantation to Promote Long-Term Survival of Allografts
1.3. In Vivo versus in Vitro Tregs Expansion to Modulate Graft Rejection
2. Molecules of the Tumor Necrosis Factor (TNF)/TNFR Superfamily Involved in Tregs Expansion
3. Redundant Functional Activity of TNFRSF Members in Tregs Differentiation and Survival
4. The Role of TNFR1 and TNFR2 in In Vivo Tregs Expansion
5. Evidence of the Anti-Inflammatory Functions of TNF and Its Role in Tregs Function
6. Role of TNFR2 in Tregs Expansion in Allogeneic Bone Marrow Transplantation and Cardiac Transplantation
7. TL1A (TNFSF15)/DR3 (TNFRSF25) Pathway
8. Concluding Remarks on the Therapeutic Implication of Targeting TNFR in Inflammatory Diseases
Funding
Conflicts of Interest
Abbreviations
FLIP | FLICE/Caspase 8 inhibitory protein |
LIP | Lymphopenia-induced proliferation |
tTregs | thymic regulatory T cells |
pTregs | peripheral regulatory T cells |
TCR | T cell receptor |
rATG | rabbit polyclonal anti-thymocyte globulin |
MHC | major histocompatibility complex |
TNFR | tumor necrosis factor receptor |
Alemtuzumab | chimeric recombinant antibody against CD52 |
IL-2 | interleukin 2 |
IL-7 | interleukin 7 |
LIP | Lymphopenia-induced proliferation |
THD | TNF homology domain |
Tregs | regulatory T cells |
TCD | T-cell depleted |
TNF | Tumor necrosis factor |
TGF-β | Tumor growth factor |
TNFRSF | TNF receptor superfamily |
Foxp3 | Forkhead box P3 transcription factor |
AIRE | Autoimmune regulator |
TCR | T cell receptor |
MHC | Major histocompatibility complex |
GvHD | Graft versus Host Disease |
tTregs | thymic Tregs |
pTregs | Peripheral Treg |
CTLA-4 (CD152) | Cytotoxic T-Lymphocyte-Associated protein 4 |
IDO | Indoleamine 2,3-dioxygenase |
LAP | Latency-Associated Protein |
ATP | Adenosine triphosphate |
ADP | Adenosine diphosphate |
AMP | Adenosine monophosphate |
rATG | rabbit anti-thymocyte globulin |
MAPK | Mitogen-activated protein kinase |
FADD | Fas-associated death domain adaptor proteins |
TRADD | TNFR1-associated death domain |
MDSC | Myeloid-derived suppressive cells |
IL-2 | Interleukin 2 |
DR3 | Death receptor 3 |
HSCT | Hematopoietic stem cell transplantation |
NF-kB | Nuclear factor kappa-light-chain-enhancer of activated B cells |
GM-CSF | Granulocyte/monocyte-colony stimulating factor |
IPEX | Immunodysregulation polyendocrinopathy and enteropathy X-linked |
MHC | major histocompatibility complex |
BMTx | bone marrow transplantation |
TNFKO | tumor necrosis factor knock-out |
STAR2 | Multimeric TNFR2 agonist |
GvHD | graft versus-host reaction |
TNFR2 | tumor necrosis factor 2 |
IL-2 | interleukin 2 |
TCD | T cell-depleted |
Tregs | regulatory T cells |
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Rodriguez-Barbosa, J.-I.; Schneider, P.; Graca, L.; Bühler, L.; Perez-Simon, J.-A.; del Rio, M.-L. The Role of TNFR2 and DR3 in the In Vivo Expansion of Tregs in T Cell Depleting Transplantation Regimens. Int. J. Mol. Sci. 2020, 21, 3347. https://doi.org/10.3390/ijms21093347
Rodriguez-Barbosa J-I, Schneider P, Graca L, Bühler L, Perez-Simon J-A, del Rio M-L. The Role of TNFR2 and DR3 in the In Vivo Expansion of Tregs in T Cell Depleting Transplantation Regimens. International Journal of Molecular Sciences. 2020; 21(9):3347. https://doi.org/10.3390/ijms21093347
Chicago/Turabian StyleRodriguez-Barbosa, Jose-Ignacio, Pascal Schneider, Luis Graca, Leo Bühler, Jose-Antonio Perez-Simon, and Maria-Luisa del Rio. 2020. "The Role of TNFR2 and DR3 in the In Vivo Expansion of Tregs in T Cell Depleting Transplantation Regimens" International Journal of Molecular Sciences 21, no. 9: 3347. https://doi.org/10.3390/ijms21093347
APA StyleRodriguez-Barbosa, J. -I., Schneider, P., Graca, L., Bühler, L., Perez-Simon, J. -A., & del Rio, M. -L. (2020). The Role of TNFR2 and DR3 in the In Vivo Expansion of Tregs in T Cell Depleting Transplantation Regimens. International Journal of Molecular Sciences, 21(9), 3347. https://doi.org/10.3390/ijms21093347