Acute Toxicity of Cu-MOF Nanoparticles (nanoHKUST-1) towards Embryos and Adult Zebrafish
Abstract
:1. Introduction
2. Results and Discussion
2.1. Characterization of the HKUST-1 Nanomaterials
2.2. Toxicity Tests
3. Materials and Methods
3.1. Synthesis of Nano-MOF Particles
3.2. Characterization
3.3. Ecotoxicity Testing
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Acknowledgments
Conflicts of Interest
References
- Simon-Yarza, T.; Rojas, S.; Horcajada, P.; Serre, C. The situation of metal-organic frameworks in biomedicine. In Reference Module in Materials Science and Materials Engineering; Elsevier: Amsterdam, The Netherlands, 2017; Volume 4. [Google Scholar] [CrossRef]
- He, H.; Li, R.; Yang, Z.; Chai, L.; Jin, L.; Alhassan, S.I.; Ren, L.; Wang, H.; Huang, L. Preparation of MOFs and MOFs derived materials and their catalytic application in air pollution: A review. Catal. Today 2020. [Google Scholar] [CrossRef]
- Feng, M.; Zhang, P.; Zhou, H.-C.; Sharma, V.K. Water-stable metal-organic frameworks for aqueous removal of heavy metals and radionuclides: A review. Chemosphere 2018, 209, 783–800. [Google Scholar] [CrossRef] [PubMed]
- Rojas, S.; Arenas-Vivo, A.; Horcajada, P. Metal-organic frameworks: A novel platform for combined advanced therapies. Coord. Chem. Rev. 2019, 388, 202–226. [Google Scholar] [CrossRef]
- Horcajada, P.; Chalati, T.; Serre, C.; Gillet, B.; Sebrie, C.; Baati, T.; Eubank, J.F.; Heurtaux, D.; Clayette, P.; Kreuz, C.; et al. Porous metal–organic-framework nanoscale carriers as a potential platform for drug delivery and imaging. Nat. Mater. 2010, 9, 172–178. [Google Scholar] [CrossRef] [PubMed]
- Mohammed, M.R.S.; Ahmad, V.; Ahmad, A.; Tabrez, S.; Choudhry, H.; Zamzami, M.A.; Bakhrebah, M.A.; Ahmad, A.; Wasi, S.; Mukhtar, H.; et al. Prospective of nanoscale metal organic frameworks [NMOFs] for cancer therapy. Semin. Cancer Biol. 2021, 69, 129–139. [Google Scholar] [CrossRef] [PubMed]
- Pandey, A.; Dhas, N.; Deshmukh, P.; Caro, C.; Patil, P.; García-Martín, M.L.; Padya, B.; Nikam, A.; Mehta, T.; Mutalik, S. Heterogeneous surface architectured metal-organic frameworks for cancer therapy, imaging, and biosensing: A state-of-the-art review. Coord. Chem. Rev. 2020, 409, 213212. [Google Scholar] [CrossRef]
- Gallis, D.F.S.; Rohwer, L.E.; Rodriguez, M.A.; Barnhart-Dailey, M.C.; Butler, K.C.; Luk, T.S.; Timlin, J.A.; Champan, K.W. Multifunctional, tunable mof materials platform for bio-imaging applications. ACS Appl. Mater. Interfaces 2017, 9, 22268–22277. [Google Scholar] [CrossRef]
- Šiller, L.; Lemloh, M.-L.; Piticharoenphun, S.; Mendis, B.G.; Horrocks, B.R.; Brümmer, F.; Medakovic, D. Silver nanoparticle toxicity in sea urchin Paracentrotus lividus. Environ. Pollut. 2013, 178, 498–502. [Google Scholar] [CrossRef]
- Zhong, X.; Zhang, Y.; Tan, L.; Zheng, T.; Hou, Y.; Hong, X.; Du, G.; Chen, X.; Zhang, Y.; Sun, X. An aluminum adjuvant-integrated nano-MOF as antigen delivery system to induce strong humoral and cellular immune responses. J. Control. Release 2019, 300, 81–92. [Google Scholar] [CrossRef]
- Giménez-Marqués, M.; Hidalgo, T.; Serre, C.; Horcajada, P. Nanostructured metal–organic frameworks and their bio-related applications. Coord. Chem. Rev. 2016, 307, 342–360. [Google Scholar] [CrossRef]
- Tamames-Tabar, C.; Cunha, D.; Imbuluzqueta, E.; Ragon, F.; Serre, C.; Blanco-Prieto, M.; Horcajada, P. Cytotoxicity of nanoscaled metal–organic frameworks. J. Mater. Chem. B 2014, 2, 262–271. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Chen, G.; Leng, X.; Luo, J.; You, L.; Qu, C.; Dong, X.; Huang, H.; Yin, X.; Ni, J. In Vitro Toxicity Study of a Porous Iron(III) Metal‒Organic Framework. Molecules 2019, 24, 1211. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Cai, X.; Xie, Z.; Li, D.; Kassymova, M.; Zang, S.-Q.; Jiang, H.-L. Nano-sized metal-organic frameworks: Synthesis and applications. Coord. Chem. Rev. 2020, 417, 213366. [Google Scholar] [CrossRef]
- Ghaffar, I.; Imran, M.; Perveen, S.; Kanwal, T.; Saifullah, S.; Bertino, M.F.; Ehrhardt, C.J.; Yadavalli, V.K.; Shah, M.R. Synthesis of chitosan coated metal organic frameworks (MOFs) for increasing vancomycin bactericidal potentials against resistant S. aureus strain. Mater. Sci. Eng. C 2019, 105, 110111. [Google Scholar] [CrossRef]
- Kohsari, I.; Shariatinia, Z.; Pourmortazavi, S.M. Antibacterial electrospun chitosan-polyethylene oxide nanocomposite mats containing ZIF-8 nanoparticles. Int. J. Biol. Macromol. 2016, 91, 778–788. [Google Scholar] [CrossRef] [PubMed]
- Thakare, S.R.; Ramteke, S.M. Fast and regenerative photocatalyst material for the disinfection of E. coli from water: Silver nano particle anchor on MOF-5. Catal. Commun. 2017, 102, 21–25. [Google Scholar] [CrossRef]
- Wyszogrodzka, G.; Marszałek, B.; Gil, B.; Dorożyński, P. Metal-organic frameworks: Mechanisms of antibacterial action and potential applications. Drug Discov. Today 2016, 21, 1009–1018. [Google Scholar] [CrossRef]
- Alavijeh, R.K.; Beheshti, S.; Akhbari, K.; Morsali, A. Investigation of reasons for metal–organic framework’s antibacterial activities. Polyhedron 2018, 156, 257–278. [Google Scholar] [CrossRef]
- Ren, F.; Yang, B.; Cai, J.; Jiang, Y.; Xu, J.; Wang, S. Toxic effect of zinc nanoscale metal-organic frameworks on rat pheochromocytoma (PC12) cells in vitro. J. Hazard. Mater. 2014, 271, 283–291. [Google Scholar] [CrossRef]
- Filippousi, M.; Turner, S.; Leus, K.; Siafaka, P.I.; Tseligka, E.D.; Vandichel, M.; Nanaki, S.G.; Vizirianakis, I.S.; Bikiaris, D.N.; Van Der Voort, P.; et al. Biocompatible Zr-based nanoscale MOFs coated with modified poly(ε-caprolactone) as anticancer drug carriers. Int. J. Pharm. 2016, 509, 208–218. [Google Scholar] [CrossRef]
- Fan, G.; Bao, M.; Zheng, X.; Hong, L.; Zhan, J.; Chen, Z.; Qu, F. Growth inhibition of harmful cyanobacteria by nanocrystalline Cu-MOF-74: Efficiency and its mechanisms. J. Hazard. Mater. 2019, 367, 529–538. [Google Scholar] [CrossRef] [PubMed]
- Wagner, A.; Liu, Q.; Rose, O.L.; Eden, A.; Vijay, A.; Rojanasakul, Y.; Dinu, C.Z. Toxicity screening of two prevalent metal organic frameworks for therapeutic use in human lung epithelial cells. Int. J. Nanomed. 2019, 14, 7583–7591. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Ruyra, À.; Yazdi, A.; Espín, J.; Carné-Sánchez, A.; Roher, N.; Lorenzo, J.; Imaz, I.; Maspoch, D. Synthesis, Culture Medium Stability, and In Vitro and In Vivo Zebrafish Embryo Toxicity of Metal-Organic Framework Nanoparticles. Chem. A Eur. J. 2015, 21, 2508–2518. [Google Scholar] [CrossRef]
- Veisi, S.; Ali Johari, S. Acute toxicity of nanoscale zeolitic imidazolate framework 8 (ZIF-8) in adult zebrafish (Danio rerio). In Proceedings of the the 3rd Nanomedicine Nanosafety Conference, Tehran, Iran, 25–26 January 2020. [Google Scholar]
- Baati, T.; Njim, L.; Neffati, F.; Kerkeni, A.; Bouttemi, M.; Gref, R.; Najjar, M.F.; Zakhama, A.; Couvreur, P.; Serre, C.; et al. In depth analysis of the in vivo toxicity of nanoparticles of porous iron(iii) metal–organic frameworks. Chem. Sci. 2013, 4, 1597–1607. [Google Scholar] [CrossRef]
- Mohamed, N.A.; Davies, R.P.; Lickiss, P.D.; Ahmetaj-Shala, B.; Reed, D.M.; Gashaw, H.H.; Saleem, H.; Freeman, G.R.; George, P.M.; Wort, S.J.; et al. Chemical and biological assessment of metal organic frameworks (MOFs) in pulmonary cells and in an acute in vivo model: Relevance to pulmonary arterial hypertension therapy. Pulm. Circ. 2017, 7, 643–653. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Fan, G.; Zhou, J.; Zheng, X.; Chen, W. Growth Inhibition of Microcystis aeruginosa by Copper-based MOFs: Performance and Physiological Effect on Algal Cells. Appl. Organomet. Chem. 2018, 32, e4600. [Google Scholar] [CrossRef]
- Kumar, P.; Anand, B.; Tsang, Y.F.; Kim, K.-H.; Khullar, S.; Wang, B. Regeneration, degradation, and toxicity effect of MOFs: Opportunities and challenges. Environ. Res. 2019, 176, 108488. [Google Scholar] [CrossRef]
- Deyko, G.S.; Isaeva, V.I.; Chernyshev, V.V.; Archipov, D.A.; Vergun, V.V.; Tkachenko, O.P.; Davshan, N.A.; Kustov, L.M. Modifying of HKUST-1 nanocrystals for selective ethane adsorption. Langmuir 2021, in press. [Google Scholar]
- Da Silva, A.F.; Da Cruz, C.; De Rezende, F.R.L.; Yamauchi, A.K.F.; Pitelli, R.A. Copper sulfate acute ecotoxicity and environmental risk for tropical fish. Acta Sci. Biol. Sci. 2014, 36, 377. [Google Scholar] [CrossRef] [Green Version]
- Palmer, F.B.; Butler, C.A.; Timperley, M.H.; Evans, C.W. Toxicity to embryo and adult zebrafish of copper complexes with two malonic acids as models for dissolved organic matter. Environ. Toxicol. Chem. 1998, 17, 1538–1545. [Google Scholar] [CrossRef]
- Hernandez, P.P.; Undurraga, C.; Gallardo, V.; MacKenzie, N.; Allende, M.L.; Reyes, A.E. Sublethal concentrations of waterborne copper induce cellular stress and cell death in zebrafish embryos and larvae. Biol. Res. 2011, 44, 7–15. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Grosell, M. Copper. Fish Physiology; Academic Press: Cambridge, MA, USA, 2011; Volume 31. [Google Scholar]
- Stouthart, A.J.H.X.; Spanings, F.A.T.; Lock, R.A.C.; Wendelaar Bonga, S.E. Effects of low water pH on lead toxicity to early life stages of the common carp (Cyprinus carpio). Aquat. Toxicol. 1994, 30, 137–151. [Google Scholar] [CrossRef] [Green Version]
- Troter, D.Z.; Todorović, Z.B.; Đokić-Stojanović, D.R.; Stamenković, O.S.; Veljković, V.B. Application of ionic liquids and deep eutectic solvents in biodiesel production: A review. Renew. Sustain. Energy Rev. 2016, 61, 473–500. [Google Scholar] [CrossRef]
- Kachala, V.V.; Khemchyan, L.L.; Kashin, A.S.; Orlov, N.V.; Grachev, A.A.; Zalesskiy, S.S.; Ananikov, V.P. Target-oriented analysis of gaseous, liquid and solid chemical systems by mass spectrometry, nuclear magnetic resonance spectroscopy and electron microscopy. Russ. Chem. Rev. 2013, 82, 648–685. [Google Scholar] [CrossRef]
- ISO. ISO/TS 18507:2015—Surface Chemical Analysis—Use of Total Reflection X-ray Fluorescence Spectroscopy in Biological and Environmental Analysis. Available online: https://www.iso.org/standard/62700.html (accessed on 16 April 2021).
- OECD. OECD test no. 236: Fish Embryo Acute Toxicity (FET) test. In OECD Guidelines for the Testing of Chemicals; Section 2; OECD: Paris, France, 2013; pp. 1–22. [Google Scholar] [CrossRef]
- Kimmel, C.B.; Ballard, W.W.; Kimmel, S.R.; Ullmann, B.; Schilling, T.F. Stages of embryonic development of the zebrafish. Dev Dyn. 1995, 203, 253–310. [Google Scholar] [CrossRef]
- OECD. Test No. 203: Fish, Acute Toxicity Testing, Section 2: Effects on Biotic Systems. Guidel. Test. Chem. 2019, 203, 10. [Google Scholar] [CrossRef]
Sample | Cu2+ Ions (CuSO4) | HKUST-1 (ὡ[Cu] = 34–35%) *, mg/L |
---|---|---|
LOEC, mg/L—embryos | 0.184 | 0.422 mg Cu/L (1.205—HKUST-1) |
LOEC, mg/L—adults | 0.050–0.100 ** | 0.375 mg Cu/L (1.071—HKUST-1) |
LC50, mg/L—embryos | 0.396 | 0.746 mg Cu/L (2.132—HKUST-1) |
LC50, mg/L—adults | 0.122–0.130 ** | 0.525 mg Cu/L (1.500—HKUST-1) |
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Abramenko, N.; Deyko, G.; Abkhalimov, E.; Isaeva, V.; Pelgunova, L.; Krysanov, E.; Kustov, L. Acute Toxicity of Cu-MOF Nanoparticles (nanoHKUST-1) towards Embryos and Adult Zebrafish. Int. J. Mol. Sci. 2021, 22, 5568. https://doi.org/10.3390/ijms22115568
Abramenko N, Deyko G, Abkhalimov E, Isaeva V, Pelgunova L, Krysanov E, Kustov L. Acute Toxicity of Cu-MOF Nanoparticles (nanoHKUST-1) towards Embryos and Adult Zebrafish. International Journal of Molecular Sciences. 2021; 22(11):5568. https://doi.org/10.3390/ijms22115568
Chicago/Turabian StyleAbramenko, Natalia, Gregory Deyko, Evgeny Abkhalimov, Vera Isaeva, Lyubov Pelgunova, Eugeny Krysanov, and Leonid Kustov. 2021. "Acute Toxicity of Cu-MOF Nanoparticles (nanoHKUST-1) towards Embryos and Adult Zebrafish" International Journal of Molecular Sciences 22, no. 11: 5568. https://doi.org/10.3390/ijms22115568