The BMP Pathway in Blood Vessel and Lymphatic Vessel Biology

Ponomarev, Ljuba C.; Ksiazkiewicz, Jakub; Staring, Michael W.; Luttun, Aernout; Zwijsen, An

doi:10.3390/ijms22126364

Open AccessReview

The BMP Pathway in Blood Vessel and Lymphatic Vessel Biology

by

Ljuba C. Ponomarev

,

Jakub Ksiazkiewicz

,

Michael W. Staring

,

Aernout Luttun

and

An Zwijsen

^*

Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology (CMVB), KU Leuven, Herestraat 49 Box 911, 3000 Leuven, Belgium

^*

Author to whom correspondence should be addressed.

Int. J. Mol. Sci. 2021, 22(12), 6364; https://doi.org/10.3390/ijms22126364

Submission received: 27 April 2021 / Revised: 31 May 2021 / Accepted: 1 June 2021 / Published: 14 June 2021

(This article belongs to the Special Issue Lymphangiogenesis in Development and Disease—Taking a Fresh Look at the Forming Lymphatics)

Download

Browse Figures

Versions Notes

Abstract

Bone morphogenetic proteins (BMPs) were originally identified as the active components in bone extracts that can induce ectopic bone formation. In recent decades, their key role has broadly expanded beyond bone physiology and pathology. Nowadays, the BMP pathway is considered an important player in vascular signaling. Indeed, mutations in genes encoding different components of the BMP pathway cause various severe vascular diseases. Their signaling contributes to the morphological, functional and molecular heterogeneity among endothelial cells in different vessel types such as arteries, veins, lymphatic vessels and capillaries within different organs. The BMP pathway is a remarkably fine-tuned pathway. As a result, its signaling output in the vessel wall critically depends on the cellular context, which includes flow hemodynamics, interplay with other vascular signaling cascades and the interaction of endothelial cells with peri-endothelial cells and the surrounding matrix. In this review, the emerging role of BMP signaling in lymphatic vessel biology will be highlighted within the framework of BMP signaling in the circulatory vasculature.

Keywords: BMP; BMP pathway fine-tuning; lymphatic vessel biology; mechano-transduction; vascular malformations; signaling cross-talk

Share and Cite

MDPI and ACS Style

Ponomarev, L.C.; Ksiazkiewicz, J.; Staring, M.W.; Luttun, A.; Zwijsen, A. The BMP Pathway in Blood Vessel and Lymphatic Vessel Biology. Int. J. Mol. Sci. 2021, 22, 6364. https://doi.org/10.3390/ijms22126364

AMA Style

Ponomarev LC, Ksiazkiewicz J, Staring MW, Luttun A, Zwijsen A. The BMP Pathway in Blood Vessel and Lymphatic Vessel Biology. International Journal of Molecular Sciences. 2021; 22(12):6364. https://doi.org/10.3390/ijms22126364

Chicago/Turabian Style

Ponomarev, Ljuba C., Jakub Ksiazkiewicz, Michael W. Staring, Aernout Luttun, and An Zwijsen. 2021. "The BMP Pathway in Blood Vessel and Lymphatic Vessel Biology" International Journal of Molecular Sciences 22, no. 12: 6364. https://doi.org/10.3390/ijms22126364

APA Style

Ponomarev, L. C., Ksiazkiewicz, J., Staring, M. W., Luttun, A., & Zwijsen, A. (2021). The BMP Pathway in Blood Vessel and Lymphatic Vessel Biology. International Journal of Molecular Sciences, 22(12), 6364. https://doi.org/10.3390/ijms22126364

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Menu

The BMP Pathway in Blood Vessel and Lymphatic Vessel Biology

Abstract

Share and Cite

Article Metrics

Article Access Statistics

Further Information

Guidelines

MDPI Initiatives

Follow MDPI