From Genetic Mutations to Molecular Basis of Heart Failure Treatment: An Overview of the Mechanism and Implication of the Novel Modulators for Cardiac Myosin
, Chian-Shiu Chien 4, Chern-En Chiang 5,6, Chen-Huan Chen 7,8 and Hao-Min Cheng 3,6,9,*Round 1
Reviewer 1 Report
Please show us the more specific and understandable figure (Fig1~3).
Author Response
Please see the attachment
Author Response File: 
Author Response.docx
Reviewer 2 Report
Thank you for permitting me to review this manuscript
Abstract
Please insert a couple of sentence on new medications
Introduction
Line 42-45 please provide reference
LIne 42-48. PLease rephrase by making 2 phrases the current one is too long
Line 49-53. please provide reference
evidence based betablocker please explain
Figure 1 must be improved by the increase in the size of the police currently it is very difficult to read
Figure 2 Please locate ryanodine receptor and insert numbers or sequence for respective events
A more concrete illustration would be helpful to better understand the new molecules such as mavacamtem right now this is not the case
Line 276 Please provide reference
conclusion
I don't see much reference in the text on gene mutations the authors speaks mainly about molecular mechanisms please insert some hints to gene mutations otherwise delete the sentence with reference to gene mutations in the title or in the conclusion
Author Response
Please see the attachment
Author Response File: Author Response.docx
