Epithelial Cell Transformation and Senescence as Indicators of Genome Aging: Current Advances and Unanswered Questions
Abstract
:1. Introduction
2. Age-Related Genetic Alterations in Normal Tissues
3. Systematization of Disease Concept According to Genome Aging Theory
4. Cells as Structural and Functional Units of Living Organisms
5. Measurement of Genome Aging
6. Age-Related Clonal Hematopoiesis
7. Age-Related Remodeling of Epithelium
8. The Mechanisms That Accelerate or Decelerate Genome Aging
8.1. DNA Damage and Cellular Senescence
8.2. Metabolism
8.3. Diet
9. Conclusions and Future Perspectives
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Kitakaze, M.; Chijimatsu, R.; Vecchione, A.; Kitagawa, T.; Doki, Y.; Eguchi, H.; Ishii, H. Epithelial Cell Transformation and Senescence as Indicators of Genome Aging: Current Advances and Unanswered Questions. Int. J. Mol. Sci. 2021, 22, 7544. https://doi.org/10.3390/ijms22147544
Kitakaze M, Chijimatsu R, Vecchione A, Kitagawa T, Doki Y, Eguchi H, Ishii H. Epithelial Cell Transformation and Senescence as Indicators of Genome Aging: Current Advances and Unanswered Questions. International Journal of Molecular Sciences. 2021; 22(14):7544. https://doi.org/10.3390/ijms22147544
Chicago/Turabian StyleKitakaze, Masatoshi, Ryota Chijimatsu, Andrea Vecchione, Toru Kitagawa, Yuichiro Doki, Hidetoshi Eguchi, and Hideshi Ishii. 2021. "Epithelial Cell Transformation and Senescence as Indicators of Genome Aging: Current Advances and Unanswered Questions" International Journal of Molecular Sciences 22, no. 14: 7544. https://doi.org/10.3390/ijms22147544