Next Article in Journal
Drosophila Larval Models of Invasive Tumorigenesis for In Vivo Studies on Tumour/Peripheral Host Tissue Interactions during Cancer Cachexia
Previous Article in Journal
Liver-Specific Overexpression of Prostasin Attenuates High-Fat Diet-Induced Metabolic Dysregulation in Mice
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 22
Issue 15
10.3390/ijms22158316
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Quantitative Radionuclide Imaging Analysis of Enhanced Drug Delivery Induced by Photoimmunotherapy

by
Winn Aung
1,*,
Atsushi B. Tsuji
1,*,
Aya Sugyo
1,
Masayuki Fujinaga
2,
Ming-Rong Zhang
2 and
Tatsuya Higashi
1
1
Department of Molecular Imaging and Theranostics, Institute for Quantum Medical Science, National Institutes for Quantum and Radiological Science and Technology (QST-iQMS), Inage, Chiba 263-8555, Japan
2
Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, National Institutes for Quantum and Radiological Science and Technology (QST-iQMS), Inage, Chiba 263-8555, Japan
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(15), 8316; https://doi.org/10.3390/ijms22158316
Submission received: 11 May 2021 / Revised: 7 July 2021 / Accepted: 29 July 2021 / Published: 2 August 2021
(This article belongs to the Section Molecular Oncology)
Browse Figures
Versions Notes

Abstract

Photoimmunotherapy (PIT) is an upcoming potential cancer treatment modality, the effect of which is improved in combination with chemotherapy. PIT causes a super-enhanced permeability and retention (SUPR) effect. Here, we quantitatively evaluated the SUPR effect using radiolabeled drugs of varying molecular weights (18F-5FU, 111In-DTPA, 99mTc-HSA-D, and 111In-IgG) to determine the appropriate drug size. PIT was conducted with an indocyanine green-labeled anti-HER2 antibody and an 808 nm laser irradiation. Mice were subcutaneously inoculated with HER2-positive cells in both hindlimbs. The tumor on one side was treated with PIT, and the contralateral side was not treated. The differences between tumor accumulations were evaluated using positron emission tomography or single-photon emission computed tomography. Imaging studies found increased tumor accumulation of agents after PIT. PIT-treated tumors showed significantly increased uptake of 18F-5FU (p < 0.001) and 99mTc-HSA-D (p < 0.001). A tendency toward increased accumulation of 111In-DTPA and 111In-IgG was observed. These findings suggest that some low- and medium-molecular-weight agents are promising candidates for combined PIT, as are macromolecules; hence, administration after PIT could enhance their efficacy. Our findings encourage further preclinical and clinical studies to develop a combination therapy of PIT with conventional anticancer drugs.
Keywords: photoimmunotherapy (PIT); super-enhanced permeability and retention (SUPR); radionuclide imaging; single-photon emission computed tomography (SPECT); positron emission tomography (PET); indocyanine green photoimmunotherapy (PIT); super-enhanced permeability and retention (SUPR); radionuclide imaging; single-photon emission computed tomography (SPECT); positron emission tomography (PET); indocyanine green

Share and Cite

MDPI and ACS Style

Aung, W.; Tsuji, A.B.; Sugyo, A.; Fujinaga, M.; Zhang, M.-R.; Higashi, T. Quantitative Radionuclide Imaging Analysis of Enhanced Drug Delivery Induced by Photoimmunotherapy. Int. J. Mol. Sci. 2021, 22, 8316. https://doi.org/10.3390/ijms22158316

AMA Style

Aung W, Tsuji AB, Sugyo A, Fujinaga M, Zhang M-R, Higashi T. Quantitative Radionuclide Imaging Analysis of Enhanced Drug Delivery Induced by Photoimmunotherapy. International Journal of Molecular Sciences. 2021; 22(15):8316. https://doi.org/10.3390/ijms22158316

Chicago/Turabian Style

Aung, Winn, Atsushi B. Tsuji, Aya Sugyo, Masayuki Fujinaga, Ming-Rong Zhang, and Tatsuya Higashi. 2021. "Quantitative Radionuclide Imaging Analysis of Enhanced Drug Delivery Induced by Photoimmunotherapy" International Journal of Molecular Sciences 22, no. 15: 8316. https://doi.org/10.3390/ijms22158316

APA Style

Aung, W., Tsuji, A. B., Sugyo, A., Fujinaga, M., Zhang, M.-R., & Higashi, T. (2021). Quantitative Radionuclide Imaging Analysis of Enhanced Drug Delivery Induced by Photoimmunotherapy. International Journal of Molecular Sciences, 22(15), 8316. https://doi.org/10.3390/ijms22158316

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop