Beneficial Effects of Soybean-Derived Bioactive Peptides
Abstract
:1. Introduction
2. Production of Soy Bioactive Peptide
3. Characteristics of Soybean Peptides
4. Functionality of Soy Peptides
4.1. Neuroprotective Effects and Improvement of Cognitive Impairment
4.2. Modulation of the Cardiovascular System and Blood Pressure
4.3. Inhibition of Chronic Kidney Disease Progression
4.4. Immunoregulatory Effects
4.5. Inhibition of Cancer Cell Proliferation by SPs
4.6. Anti-Inflammation Properties
4.7. Modulation of Lipid Metabolism
4.8. Antiobesity Effects
4.9. Antiarteriosclerosis Effects
4.10. Antidiabetic Effects
4.11. Skin Protection Effect of Soybean Oligopeptides against Ultraviolet Radiation
4.12. Antioxidative Properties
4.13. Soybean Proteins and Control of Increased Gut Microbial Activity Caused by Probiotics
4.14. Antimicrobial and Antiviral Effects
5. Economic Feasibility and Application of Soybean-Derived Bioactive Peptides
6. Conclusions and Perspectives
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
References
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Peptide Sequence | Biological Effect | Reference |
---|---|---|
VHVV | Neuroprotection | [48] |
IVF, LLF, LNF, LSW, LEF | ACE inhibitory | [51] |
NWGPLV | ACE inhibitory | [52] |
FRADHPFL, RADHPF | Lowering blood pressure and vasorelaxation | [53,54] |
IFL, WL | ACE inhibitory | [55] |
HSYNLRQSQVSELKYEGNWGPLV NPESQQGSPRV | ACE inhibitory and antioxidant | [56] |
FRADHPFL, RADHPF | Lowering blood pressure and vasorelaxation | [53,54] |
LLPVFK, RLPKPW | Anti-hypertensive | [57] |
PGTAVPK | Anti-hypertensive | [58] |
MITLAIPVNKPGR | Immunoregulatory | [59] |
QQQQQQKSHGGR | Immunoregulatory | [60] |
LITLAIPVNKPGR | Immunoregulatory | [61] |
Lunasin (KWQHQQSCRKQLQGVNLTPCDD DDDDDDDEKHIMEKIQGRGDDDD DDD DDEKH IMEKIQ) | Anticancer, anti-inflammatory, antioxidant and cholesterol regulation | [62,63,64,65,66] |
QQQQQGGSQSQ, QEPQESQQ, QQQQQGGSQSQSQKG, PETMQQQQQQ, | Anti-cancer | [67] |
QRPR | Anti-inflammatory | [68] |
RGD | Anti-inflammatory | [65,69] |
Soystatin (VAWWMY) | Cholesterol regulation | [42,70] |
Lactostatin (IIAEK) | Cholesterol regulation | [71,72,73] |
Lactostensin (HIRL) | Cholesterol regulation | [74] |
LPYPR, WGAPSL | Cholesterol regulation | [75] |
IAVPGEVA, IAVPTGVA, LPYP | Cholesterol regulation and lipid metabolism | [76] |
HIRL, DPR, FVVNATSN | Hypocholesterolemic | [75] |
YVVNPDNDEN, YVVNPDNNEN | Hypocholesterolemic | [76] |
DPR, VPDPR, APGPR, VPGPR | Hypocholesterolemic | [77,78,79] |
GCTLN, QDF | Hypolipidemic | [80] |
IAVPGEVA, IAVPTGVA, LPYP | Hypolipidemic | [81] |
Lupin peptides (LIPKHSDAD, LTFPGSAED, GDEQSHQDEGVIVR) | Hypolipidemic and hypocholesterolemic | [82,83,84] |
VVVP, YPFVV | Hypotriglyceridemic | [42,85] |
WE | Hypocholesterolemic and hypotriglyceridemic | [86] |
Enterostatin (VPDPR) | Hypocholesterolemic and hypotriglyceridemic | [87] |
Soymorphin-5 (YPFVV) | Hypotriglyceridemic and anti-diabetic | [88] |
KRES, FREL | Hypotriglyceridemic antioxidant, anti-inflammatory and anti-atherogenic | [42,89] |
KNPQLR, EIPEKNPQLR, RKQEEDEDEEQQRE | FAS inhibitor | [90] |
KNPQLR, EIPEKNPQLR, RKQEEDEDEEQQRE | Hypotriglyceridemic and FAS inhibitor | [42] |
ILL, LLL, VHVV | Lipolysis and anti-obesity | [91] |
SY | Anti-obesity | [92] |
CKGGRAKDC | Anti-obesity | [93] |
DWFKAFYDKVAEKFKEAF | Anti-arteriosclerosis | [94] |
FREL | Anti-arteriosclerosis | [89] |
WH | Anti-arteriosclerosis | [95] |
IAVPTGVA | Anti-diabetic | [96] |
AKSPLF, ATNPLF, FEELN, LSVSVL | Anti-diabetic | [97] |
Vglycin (VSCNGVCSPFEMPPCGSS ACRCIPYGLVVGNCRHPSG) | Anti-diabetic | [98] |
HHL | ACE inhibitory and antioxidant | [99] |
FDPAL | Antioxidant | [100] |
LLPLPVLK, SWLRL, WLRL | Antioxidant | [101] |
LH, VNPESQQGSPR | Antioxidant | [102] |
Selenium (Se)-containing peptide [SFQ(K)SeM and SeCPEE] | Antioxidant | [103] |
Thiol-containing peptides containing Tyr, Met, His, Lys, and Cys | Antioxidant | [104] |
GNPDIEHPE, TNDRPSIG, SVIKPPTDE, VIKPPTDE, GNPDIEHPET, LVPPQESQ, EITPEKNPQ, TLVNNDDRDS, NSQHPEL, FEEPQQPQ | Antioxidant | [105] |
PGTAVFK, IKAFKEATKVDKVVVLWTA | Antimicrobial | [106] |
KHPHGRSYKTKLRILA, LRFRAPAPVLRRIAKR, HTSKALLDMLKRLGK | Antimicrobial | [107] |
ALPEEVIQHTFNLKSQ | Antiviral | [108] |
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Kim, I.-S.; Yang, W.-S.; Kim, C.-H. Beneficial Effects of Soybean-Derived Bioactive Peptides. Int. J. Mol. Sci. 2021, 22, 8570. https://doi.org/10.3390/ijms22168570
Kim I-S, Yang W-S, Kim C-H. Beneficial Effects of Soybean-Derived Bioactive Peptides. International Journal of Molecular Sciences. 2021; 22(16):8570. https://doi.org/10.3390/ijms22168570
Chicago/Turabian StyleKim, Il-Sup, Woong-Suk Yang, and Cheorl-Ho Kim. 2021. "Beneficial Effects of Soybean-Derived Bioactive Peptides" International Journal of Molecular Sciences 22, no. 16: 8570. https://doi.org/10.3390/ijms22168570