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Review
Peer-Review Record

Targeted and Non-Targeted Mechanisms for Killing Hypoxic Tumour Cells—Are There New Avenues for Treatment?

Int. J. Mol. Sci. 2021, 22(16), 8651; https://doi.org/10.3390/ijms22168651
by Alyssa Gabrielle Apilan * and Carmel Mothersill
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2021, 22(16), 8651; https://doi.org/10.3390/ijms22168651
Submission received: 29 June 2021 / Revised: 7 August 2021 / Accepted: 9 August 2021 / Published: 11 August 2021
(This article belongs to the Special Issue Molecular Research in Radiobiology)

Round 1

Reviewer 1 Report

This review provides a comprehensive summary of the current state of play in cancer therapeutics exploiting tumor hypoxia. The review is well organised and although somewhat long for the messages it contains, will be a useful source of reference for the field, and is a useful and novel overview regarding bystander effects in this area. The problem I found was that in many places the english was idiosyncratic or contained grammatical or syntactical errors; these should be carefully edited. The only suggestion I have for a change in content is that the mechanism of the apparently paradoxical application of hyperbaric oxygen should be explained. The number of places that need editorial attention is such that I have highlighted them on the PDF and attach to this review for the authors benefit.

Comments for author File: Comments.pdf

Author Response

Please see the attachment. 

Author Response File: Author Response.docx

Reviewer 2 Report

none

Author Response

Thank you for the positive feedback. 

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