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Review

Iron Complexes of Flavonoids-Antioxidant Capacity and Beyond

by
Zdeněk Kejík
1,2,3,
Robert Kaplánek
1,2,3,
Michal Masařík
1,2,4,5,
Petr Babula
4,
Adam Matkowski
6,
Petr Filipenský
7,
Kateřina Veselá
1,2,3,
Jakub Gburek
8,
David Sýkora
1,3,
Pavel Martásek
1 and
Milan Jakubek
1,2,3,*
1
Department of Paediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University and General University Hospital in Prague, CZ-121 08 Prague, Czech Republic
2
BIOCEV, First Faculty of Medicine, Charles University, Prague, CZ-252 50 Vestec, Czech Republic
3
Department of Analytical Chemistry, Faculty of Chemical Engineering, University of Chemistry and Technology, CZ-166 28 Prague, Czech Republic
4
Department of Physiology, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic
5
Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic
6
Department of Pharmaceutical Biology and Botany, Wroclaw Medical University, Borowska 211, 50556 Wroclaw, Poland
7
Department of Urology, St. Anne’s University Hospital Brno, Pekařská 53, 656 91 Brno, Czech Republic
8
Department of Pharmaceutical Biochemistry, Wroclaw Medical University, Borowska 211A, 50556 Wroclaw, Poland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(2), 646; https://doi.org/10.3390/ijms22020646
Submission received: 4 December 2020 / Revised: 30 December 2020 / Accepted: 2 January 2021 / Published: 11 January 2021
(This article belongs to the Special Issue Antioxidant and Prooxidant Properties of Flavonoids)
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Abstract

Flavonoids are common plant natural products able to suppress ROS-related damage and alleviate oxidative stress. One of key mechanisms, involved in this phenomenon is chelation of transition metal ions. From a physiological perspective, iron is the most significant transition metal, because of its abundance in living organisms and ubiquitous involvement in redox processes. The chemical, pharmaceutical, and biological properties of flavonoids can be significantly affected by their interaction with transition metal ions, mainly iron. In this review, we explain the interaction of various flavonoid structures with Fe(II) and Fe(III) ions and critically discuss the influence of chelated ions on the flavonoid biochemical properties. In addition, specific biological effects of their iron metallocomplexes, such as the inhibition of iron-containing enzymes, have been included in this review.
Keywords: flavonoids; iron ions; metallocomplexes flavonoids; iron ions; metallocomplexes
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MDPI and ACS Style

Kejík, Z.; Kaplánek, R.; Masařík, M.; Babula, P.; Matkowski, A.; Filipenský, P.; Veselá, K.; Gburek, J.; Sýkora, D.; Martásek, P.; et al. Iron Complexes of Flavonoids-Antioxidant Capacity and Beyond. Int. J. Mol. Sci. 2021, 22, 646. https://doi.org/10.3390/ijms22020646

AMA Style

Kejík Z, Kaplánek R, Masařík M, Babula P, Matkowski A, Filipenský P, Veselá K, Gburek J, Sýkora D, Martásek P, et al. Iron Complexes of Flavonoids-Antioxidant Capacity and Beyond. International Journal of Molecular Sciences. 2021; 22(2):646. https://doi.org/10.3390/ijms22020646

Chicago/Turabian Style

Kejík, Zdeněk, Robert Kaplánek, Michal Masařík, Petr Babula, Adam Matkowski, Petr Filipenský, Kateřina Veselá, Jakub Gburek, David Sýkora, Pavel Martásek, and et al. 2021. "Iron Complexes of Flavonoids-Antioxidant Capacity and Beyond" International Journal of Molecular Sciences 22, no. 2: 646. https://doi.org/10.3390/ijms22020646

APA Style

Kejík, Z., Kaplánek, R., Masařík, M., Babula, P., Matkowski, A., Filipenský, P., Veselá, K., Gburek, J., Sýkora, D., Martásek, P., & Jakubek, M. (2021). Iron Complexes of Flavonoids-Antioxidant Capacity and Beyond. International Journal of Molecular Sciences, 22(2), 646. https://doi.org/10.3390/ijms22020646

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