11,12 Epoxyeicosatrienoic Acid Rescues Deteriorated Wound Healing in Diabetes
, Jasmina Sterz 1, Johannes Frank 1, Ingo Marzi 1 and Anna Lena Sander 1Round 1
Reviewer 1 Report
I have read the work carefully and the manuscript has been substantially improved as the fibroblast result has been introduced. As for the photographs that are found to be fundamental for the type of work published, once again examining the pdf they are not at good resolution. However, I believe that this is a problem relating to the computer methods that the system uses to assemble the final document (ie in pdf). I might suggest placing the photos in another document and considering it supplementary. This would ensure that the photographs were shown in their original format and would allow the referee to observe them better
Author Response
Thank you for your nice comment.
Photographs will be attached to the sublemet section for publication.
Manuscript underwent professionel English correction at American Manuscript Editors.
Reviewer 2 Report
The work titled "11,12 epoxyeicosatrienoic acid rescues deteriorated wound healing in diabetes" describes the investigation on the effect of 11,12 EET in the diabetes wound healing. The local ETT application is able to promote wound closure in induced diabetes mice in a shorter time than to untreated mice. This behavior is associated to the enhancement of angiogenesis and related growth factors.
The paper is overall well written, the introduction is very clear and the background is well explained from the authors. Furthermore, the results are clearly presented.
I think that it is an interesting study in the field of diabetes wound healing management and i recommend it for the pubblication in the IJMS journal.
A minor check is required because there are in the text some sentences in a different font with respect to the template : line 15-31, 40-41, 64-65, 70-72, 346-350
Author Response
Thank you for your kind remark.
Fonts were standardized.
