Next Article in Journal
Effect of Epigallocatechin-3-Gallate on EGFR Signaling and Migration in Non-Small Cell Lung Cancer
Next Article in Special Issue
On Placental Toxicology Studies and Cerium Dioxide Nanoparticles
Previous Article in Journal
The Beneficial Effects of Essential Oils in Anti-Obesity Treatment
Previous Article in Special Issue
Novel Biomolecules in the Pathogenesis of Gestational Diabetes Mellitus
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 22
Issue 21
10.3390/ijms222111831
Review Report
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Review
Peer-Review Record

Periodontitis and Gestational Diabetes Mellitus: A Potential Inflammatory Vicious Cycle

Int. J. Mol. Sci. 2021, 22(21), 11831; https://doi.org/10.3390/ijms222111831
by María José Bendek 1, Gisela Canedo-Marroquín 1, Ornella Realini 1, Ignacio N. Retamal 1, Marcela Hernández 2, Anilei Hoare 3, Dolores Busso 4,5, Lara J. Monteiro 4,5, Sebastián E. Illanes 4,5 and Alejandra Chaparro 1,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2021, 22(21), 11831; https://doi.org/10.3390/ijms222111831
Submission received: 18 October 2021 / Revised: 26 October 2021 / Accepted: 27 October 2021 / Published: 31 October 2021
(This article belongs to the Special Issue Pathogenesis of Pregnancy-Related Complications 2.0)

Round 1

Reviewer 1 Report

A well researched, well illustrated and largely written paper. Only minor criticisms. Many of the sentences are very long and would be more readable if broken up into sentences that include a single idea. Some seem to lack the correct wording or are incomplete such as "Moreover, the risk for PE increased with both, periodontitis and GDM in 20-fold more (HR = 19.96, 95% CI: 7.62-52.31, p-value = 0.001) [66–68]". Maybe a grammar check of the manuscript would provide a simple solution. You quote the "Dysbiotic theory" but I feel that the "Dysbiotic hypothesis" would be more appropriate.

Author Response

Please see the attachment

Author Response File: Author Response.pdf

Reviewer 2 Report

[General]

The authors reviewed the association between periodontal disease and gestational diabetes mellitus (GDM) from the wide points such as the epidemiology, proinflammatory molecules , and extracellular vesicles (EVs). Particularly, the role of EVs from placenta and periodontal tissue in GDM onset is of interest. Therefore, this review is meaningful and beneficial to the readers. 

However, several improvements are needed as described below.

 

[Major points]

  1. The results of epidemiological studies are important to judge the association between various factors and disease onset. The tabulation of these data is easy to understand for readers. Therefore, please tabulate the results of epidemiological studies. Candidate titles are as follows. Table 1 Association between GDM onset and periodontal disease and preeclampsia (line 184-202). Table 2 Association between obesity and periodontal disease  (Line 184-202).

 

[Minor points]

  1. (Line 351-352) I think that positive/negative predictive values (PPV/NPV) are unnecessary in review because PPV/NPV are affected by prevalence. 
  1. Please change “p-value = ***” to “p = ***” because the latter term is more general. Moreover, too small P value is not necessary. “P < 0.001” is sufficient.
  1. typo: unnecessary hyphen should be removed (periodonti-tis in line 18, 21, and 29; sus-ceptible in line 19; in-tercellular in line 31; pre-eclampsia in line 74; preg-nancies in line 101).
  1. (References) Numbers before authors should be deleted.

Comments for author File: Comments.pdf

Author Response

Please see the attachment

Author Response File: Author Response.pdf

Back to TopTop