Potential Physiological Relevance of ERAD to the Biosynthesis of GPI-Anchored Proteins in Yeast
Abstract
:1. Introduction
2. ER-Associated Degradation in Yeast
2.1. The Hrd1 Pathway
2.2. The Doa10 Pathway
3. GPI-Anchored Proteins
4. Quality Control of GPI-Anchored Proteins
5. Potential Physiological Relevance of ERAD to the Biosynthesis of GPI-Anchored Proteins
5.1. Genetic Interactions between GPI and ERAD Genes
5.2. Quality Control of Proteins that Harbor the GPI Anchoring Signal in the Cytosol
5.3. Exit of GPI-Anchored Proteins from the ER Is Affected by the Perturbation of Manganese Homeostasis
5.4. Possible Involvement of ERAD in the Maintenance of Manganese Homeostasis
6. Conclusions
Supplementary Materials
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
ERAD | Endoplasmic reticulum-associated degradation |
EGTA | Ethylene glycol-bis(β-aminoethyl ether)-N,N,N′,N′-tetra-acetic acid |
GPI | Glycosylphosphatidylinositol |
EtN-P | Ethanolamine phosphate |
Man | Mannose |
GlcN | Glucosamine |
GlcNAc | N-Acetylglucosamine |
UPR | Unfolded protein response |
prERAD | Pre-insertional ERAD |
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GPI2 | GPI8 | GPI10 | GPI11 | GPI13 | GPI16 | GPI17 | GPI19 | |
---|---|---|---|---|---|---|---|---|
HRD1 | P | P | P | P | ||||
HRD3 | P | P | P | N | ||||
UBC7 | P | P | P | |||||
USA1 | P | P | P | P | ||||
DER1 | N | P | P | |||||
YOS9 | P | N | N | |||||
DOA10 | P |
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Nakatsukasa, K. Potential Physiological Relevance of ERAD to the Biosynthesis of GPI-Anchored Proteins in Yeast. Int. J. Mol. Sci. 2021, 22, 1061. https://doi.org/10.3390/ijms22031061
Nakatsukasa K. Potential Physiological Relevance of ERAD to the Biosynthesis of GPI-Anchored Proteins in Yeast. International Journal of Molecular Sciences. 2021; 22(3):1061. https://doi.org/10.3390/ijms22031061
Chicago/Turabian StyleNakatsukasa, Kunio. 2021. "Potential Physiological Relevance of ERAD to the Biosynthesis of GPI-Anchored Proteins in Yeast" International Journal of Molecular Sciences 22, no. 3: 1061. https://doi.org/10.3390/ijms22031061