Natriuretic Peptide Expression and Function in GH3 Somatolactotropes and Feline Somatotrope Pituitary Tumours
Abstract
:1. Introduction
2. Results
2.1. Molecular Characterization of a Custom Multiplex RT-qPCR Assay for Natriuretic Peptides and Somatotrope Markers in GH3 Somatolactotropes and Primary Rat Pituitary Tissue
2.2. cAMP and TRH Signalling Pathways Differentially Regulate Expression of Natriuretic Peptides and Their Receptors
2.3. Identification of Putative CNP Target Genes in GH3 Somatolactotropes
2.4. Interaction of Oestrogen and Natriuretic Peptides in GH3 Somatolactotropes
2.5. Natriuretic Peptide System in Feline Somatotrope Tumours
3. Materials and Methods
3.1. Materials
3.2. Cell Culture and cGMP Enzyme Immunoassay
3.3. Patient Data, Ethics, and Hypophysectomy Surgery
3.4. RNA Extraction
3.5. GeXP Multiplex RT-qPCR
3.6. Immunoassays and Vaginal Cytology
3.7. Data Presentation and Statistical Analyses
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Mirczuk, S.M.; Scudder, C.J.; Read, J.E.; Crossley, V.J.; Regan, J.T.; Richardson, K.M.; Simbi, B.; McArdle, C.A.; Church, D.B.; Fenn, J.; et al. Natriuretic Peptide Expression and Function in GH3 Somatolactotropes and Feline Somatotrope Pituitary Tumours. Int. J. Mol. Sci. 2021, 22, 1076. https://doi.org/10.3390/ijms22031076
Mirczuk SM, Scudder CJ, Read JE, Crossley VJ, Regan JT, Richardson KM, Simbi B, McArdle CA, Church DB, Fenn J, et al. Natriuretic Peptide Expression and Function in GH3 Somatolactotropes and Feline Somatotrope Pituitary Tumours. International Journal of Molecular Sciences. 2021; 22(3):1076. https://doi.org/10.3390/ijms22031076
Chicago/Turabian StyleMirczuk, Samantha M., Christopher J. Scudder, Jordan E. Read, Victoria J. Crossley, Jacob T. Regan, Karen M. Richardson, Bigboy Simbi, Craig A. McArdle, David B. Church, Joseph Fenn, and et al. 2021. "Natriuretic Peptide Expression and Function in GH3 Somatolactotropes and Feline Somatotrope Pituitary Tumours" International Journal of Molecular Sciences 22, no. 3: 1076. https://doi.org/10.3390/ijms22031076