Next Article in Journal
Molecular Mechanisms of DUBs Regulation in Signaling and Disease
Next Article in Special Issue
Transglutaminases Are Active in Perivascular Adipose Tissue
Previous Article in Journal
A Two-in-One Strategy: Target and Nontarget Site Mechanisms Both Play Important Role in IMI-Resistant Weedy Rice
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 22
Issue 3
10.3390/ijms22030984
Review Report
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Article
Peer-Review Record

TGFβ-1 Induced Cross-Linking of the Extracellular Matrix of Primary Human Dermal Fibroblasts

Int. J. Mol. Sci. 2021, 22(3), 984; https://doi.org/10.3390/ijms22030984
by Mariya E. Semkova * and J. Justin Hsuan
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2021, 22(3), 984; https://doi.org/10.3390/ijms22030984
Submission received: 21 December 2020 / Revised: 8 January 2021 / Accepted: 11 January 2021 / Published: 20 January 2021
(This article belongs to the Special Issue Tissue Transglutaminase in Physio-Pathological Conditions)

Round 1

Reviewer 1 Report

In this study, the authors hypothesized that increased ECM cross-linking by TGFβ contributes to skin fibrosis in Systemic Sclerosis (SSc) and they have mapped novel cross-links between ECM proteins and demonstrated that activation of TGFβ signaling in cultured dermal fibroblasts upregulates multiple cross-linking enzymes in the ECM and alters cross-linking between fibrinogen and collagen V.

Comments and suggestions:

In the introduction section, the authors should add more data about fibrosis disorders.

The section regarding used statistics is missing. The authors must add it.

In the Discussion section: please provide the limitations and clinical pitfalls of the study.

Consider revising accordingly.

Author Response

Thank you for your comments.

We have made the necessary changes as requested (see attached file).

  • More information about the cause and relevant molecular pathways in fibrotic diseases has been added in the Introduction 
  • Section 4.6 Statistical Analysis has been added in the Materials and Methods
  • The limitations of the study have been further discussed in the last paragraph of the Discussion

Author Response File: Author Response.docx

Reviewer 2 Report

The present manuscript sounds well written and novel.

The study is original and relevant in the field.

Methods are correct and rigorous. Tables and Figures are clear, useful and high qualitative. Findings interpretation and discussion are correct.

English is good and easy to read.

 

 

Author Response

Thank you for your comments.

Some changes have been made as requested by the first reviewer (see attached file).

  • More information about the cause and relevant molecular pathways in fibrotic diseases have been added in the Introduction
  • Section 4.6 Statistical analysis has been added in the Materials and Methods
  • The limitations of the study have been further discussed in the last paragraph of the Discussion

Author Response File: Author Response.docx

Back to TopTop