Discovering the Lost Reward: Critical Locations for Endocannabinoid Modulation of the Cortico–Striatal Loop That Are Implicated in Major Depression
Abstract
:1. Major Depression: Diagnostic Criteria, Prevalence and Etiology
2. Dopamine and Major Depression
2.1. Location of DA Activity within Subcortical Circuits
2.2. Top-Down Bottom-Up Cortical DA Connectivity with Subcortical Circuits
2.3. The Excitation-Inhibition Imbalance
3. The Reward Circuits and Major Depression
3.1. The Striatum and the Mesolimbic Area
3.2. The Striosomal Compartment of Striatum
4. The Endocannabinoid System and Major Depression
5. The Crosstalk between Dopamine, Striosomes and Endocannabinoid Receptors
6. The CB1 Crosstalk with the Striosomal Activity on the Molecular Level
7. Vulnerability of Dopamine and Endocannabinoid Systems within the Reward Circuits: Implications for Major Depression
8. Insufficiency of Past and Current Pharmacological Treatments for Major Depression: Implications for Novel Treatment with CBD
9. For Further Research
10. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Acknowledgments
Conflicts of Interest
References
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Goldstein Ferber, S.; Weller, A.; Yadid, G.; Friedman, A. Discovering the Lost Reward: Critical Locations for Endocannabinoid Modulation of the Cortico–Striatal Loop That Are Implicated in Major Depression. Int. J. Mol. Sci. 2021, 22, 1867. https://doi.org/10.3390/ijms22041867
Goldstein Ferber S, Weller A, Yadid G, Friedman A. Discovering the Lost Reward: Critical Locations for Endocannabinoid Modulation of the Cortico–Striatal Loop That Are Implicated in Major Depression. International Journal of Molecular Sciences. 2021; 22(4):1867. https://doi.org/10.3390/ijms22041867
Chicago/Turabian StyleGoldstein Ferber, Sari, Aron Weller, Gal Yadid, and Alexander Friedman. 2021. "Discovering the Lost Reward: Critical Locations for Endocannabinoid Modulation of the Cortico–Striatal Loop That Are Implicated in Major Depression" International Journal of Molecular Sciences 22, no. 4: 1867. https://doi.org/10.3390/ijms22041867