The In Vivo Selection Method in Breast Cancer Metastasis
Abstract
:1. Introduction
2. Differences in Transplantation Methods for the In Vivo Selection
2.1. Differences in Highly Metastatic Breast Cancer Cell Lines
2.2. Breast Cancer Metastasis in PDX Models
3. Highly Metastatic Breast Cancer Cell Lines
3.1. Introduction of Highly Metastatic Breast Cancer Cell Lines
3.2. Lung Metastasis
3.3. Bone Metastasis
3.4. Brain Metastasis
3.5. Liver Metastasis
3.6. Lymph Node Metastasis
4. Differences in Metastasis Gene Signatures According to the Molecular Subtypes of Breast Cancer
5. Genomic Profiling of Breast Cancer
6. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
SCID | Severe combined immunodeficiency |
NOD | Non-obese diabetic |
GEMM | Genetically engineered mouse model |
PDX | Patient derived xenograft |
MetMap | Metastasis map |
QOL | Quality of life |
BBB | Blood-brain barrier |
HR | Hormone receptor |
HER2 | Human epidermal growth factor receptor 2 |
ER | Estrogen receptor |
PR | Progesterone receptor |
TNBC | Triple negative breast cancer |
EMT | Epithelial to mesenchymal transition |
TCGA | The cancer genome atlas |
METABRIC | Molecular taxonomy of breast cancer international consortium |
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PDX Models | Subtype | Method | Metastatic Organs | Reference |
---|---|---|---|---|
3887-LM | Basal-like (TNBC) | Orthotopic | Lung | [36] |
HCI-002 LM2-1 | TNBC | Orthotopic | Lung | [38] |
Brain PDX (B0~B3) | TNBC | Intracranially | Brain | [39] |
MFP PDX (M0~M3) | TNBC | Orthotopic | Brain | [39] |
Cell Line | Species of Origin | Subtype | Method | Metastatic Organ | References |
---|---|---|---|---|---|
4T1-2776, 2792, 2869 | Mouse | Basal-like (TNBC) | Spleen transplantation | Liver | [61] |
4T1.3 | Mouse | Basal-like (TNBC) | Orthotopic | Bone | [62] |
4T1E/M3 | Mouse | Basal-like (TNBC) | Intravenous | Bone | [63] |
4T1LM | Mouse | Basal-like (TNBC) | Orthotopic | Liver | [64] |
C3L5 | Mouse | Unknown | Subcutaneous | Lung | [65] |
CN34-LM1 | Human | Claudin-low (TNBC) | Intravenous | Lung | [66] |
MCF7-BM02 | Human | Luminal A | Intracaudal arterial | Bone | [67] |
MDA-MB-231-BM (BoM: 1833) | Human | Claudin-low (TNBC) | Intracardiac | Bone | [45] |
MDA-MB-231-HM | Human | Claudin-low (TNBC) | Intravenous | Lung | [68] |
MDA-MB-231-HM.LNm5 | Human | Claudin-low (TNBC) | Orthotopic | Lymph node | [69] |
MDA-MB-231-LM05 | Human | Claudin-low (TNBC) | Orthotopic | Lung | [26] |
MDA-MB-231-LM1-2-1 | Human | Claudin-low (TNBC) | Intravenous | Lung | [26] |
MDA-MB-231-LM2 (4175) | Human | Claudin-low (TNBC) | Intracardiac/Intravenous | Lung | [25] |
MDA-MB-231-luc-D3H2LN | Human | Claudin-low (TNBC) | Orthotopic | Lymph node | [50] |
MDA-MB-231HMLNm5 | Human | Claudin-low (TNBC) | Orthotopic | Lung, Liver, Lymph node, Spleen and Paraspinal tissue | [69,70,71] |
MDA-MB-468LN | Human | Basal-like (TNBC) | Orthotopic | Lymph node | [72] |
mtMDA | Human | Claudin-low (TNBC) | Intracardiac | Bone | [73] |
SUM159-M1a | Human | Claudin-low (TNBC) | Intravenous | Lung | [74] |
Metastasis Organ | Gene Signatures | Reference |
---|---|---|
Lung | EREG, CXCL1, MMP1, MMP2, SPARC, VCAM1, COX2 | [25] |
Lung | CD70, SOX4 | [66] |
Bone | IL1, CTGF, CXCR4, OPN | [45] |
Bone | DKK1 | [87] |
Bone | S100A4 | [73] |
Brain | COX2, HBEGF, ST6GALNAC5 | [91] |
Brain | CTSS, L1CAM, GRIN2B, PCDH7, CX43 | [18,95,96,97] |
Liver | CLDN2 | [61] |
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Nakayama, J.; Han, Y.; Kuroiwa, Y.; Azuma, K.; Yamamoto, Y.; Semba, K. The In Vivo Selection Method in Breast Cancer Metastasis. Int. J. Mol. Sci. 2021, 22, 1886. https://doi.org/10.3390/ijms22041886
Nakayama J, Han Y, Kuroiwa Y, Azuma K, Yamamoto Y, Semba K. The In Vivo Selection Method in Breast Cancer Metastasis. International Journal of Molecular Sciences. 2021; 22(4):1886. https://doi.org/10.3390/ijms22041886
Chicago/Turabian StyleNakayama, Jun, Yuxuan Han, Yuka Kuroiwa, Kazushi Azuma, Yusuke Yamamoto, and Kentaro Semba. 2021. "The In Vivo Selection Method in Breast Cancer Metastasis" International Journal of Molecular Sciences 22, no. 4: 1886. https://doi.org/10.3390/ijms22041886