Resveratrol as Chemosensitizer Agent: State of Art and Future Perspectives

Cocetta, Veronica; Quagliariello, Vincenzo; Fiorica, Francesco; Berretta, Massimiliano; Montopoli, Monica

doi:10.3390/ijms22042049

Open AccessReview

Resveratrol as Chemosensitizer Agent: State of Art and Future Perspectives

by

Veronica Cocetta

¹

,

Vincenzo Quagliariello

²

,

Francesco Fiorica

³

,

Massimiliano Berretta

^4,*

and

Monica Montopoli

^1,5,*

¹

Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy

²

Division of Cardiology, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, 80131 Napoli, Italy

³

Department of Radiation Oncology, Az. ULSS 9 Scaligera, 37045 Legnago, VR, Italy

⁴

Department of Clinical and Experimental Medicine, University of Messina, 98122 Messina, Italy

⁵

Veneto Institute of Molecular Medicine, VIMM, 35129 Padova, Italy

^*

Authors to whom correspondence should be addressed.

Int. J. Mol. Sci. 2021, 22(4), 2049; https://doi.org/10.3390/ijms22042049

Submission received: 28 January 2021 / Revised: 13 February 2021 / Accepted: 16 February 2021 / Published: 19 February 2021

(This article belongs to the Special Issue Health Benefits of Resveratrol 2.0)

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Abstract

Resistance to chemotherapy still remains a major challenge in the clinic, impairing the quality of life and survival rate of patients. The identification of unconventional chemosensitizing agents is therefore an interesting aspect of cancer research. Resveratrol has emerged in the last decades as a fascinating molecule, able to modulate several cancer-related molecular mechanisms, suggesting a possible application as an adjuvant in cancer management. This review goes deep into the existing literature concerning the possible chemosensitizing effect of resveratrol associated with the most conventional chemotherapeutic drugs. Despite the promising effects observed in different cancer types in in vitro studies, the clinical translation still presents strong limitations due to the low bioavailability of resveratrol. Recently, efforts have been moved in the field of drug delivery to identifying possible strategies/formulations useful for a more effective administration. Despite the necessity of a huge implementation in this research area, resveratrol appears as a promising molecule able to sensitize resistant tumors to drugs, suggesting its potential use in therapy-refractory cancer patients.

Keywords: resveratrol; chemosensitization; chemotherapy resistance; cancer; drug resistance; integrative medicine

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MDPI and ACS Style

Cocetta, V.; Quagliariello, V.; Fiorica, F.; Berretta, M.; Montopoli, M. Resveratrol as Chemosensitizer Agent: State of Art and Future Perspectives. Int. J. Mol. Sci. 2021, 22, 2049. https://doi.org/10.3390/ijms22042049

AMA Style

Cocetta V, Quagliariello V, Fiorica F, Berretta M, Montopoli M. Resveratrol as Chemosensitizer Agent: State of Art and Future Perspectives. International Journal of Molecular Sciences. 2021; 22(4):2049. https://doi.org/10.3390/ijms22042049

Chicago/Turabian Style

Cocetta, Veronica, Vincenzo Quagliariello, Francesco Fiorica, Massimiliano Berretta, and Monica Montopoli. 2021. "Resveratrol as Chemosensitizer Agent: State of Art and Future Perspectives" International Journal of Molecular Sciences 22, no. 4: 2049. https://doi.org/10.3390/ijms22042049

APA Style

Cocetta, V., Quagliariello, V., Fiorica, F., Berretta, M., & Montopoli, M. (2021). Resveratrol as Chemosensitizer Agent: State of Art and Future Perspectives. International Journal of Molecular Sciences, 22(4), 2049. https://doi.org/10.3390/ijms22042049

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Resveratrol as Chemosensitizer Agent: State of Art and Future Perspectives

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