Mast Cell Involvement in Fibrosis in Chronic Graft-Versus-Host Disease
Abstract
:1. Introduction
2. Canonical Immune Involvement in GVHD
3. Historical Perspective on Mast Cells in Fibrotic Chronic GVHD
4. Mast Cells as Immunoregulatory Cells in Acute GVHD
5. Mouse Models of Fibrotic Chronic GVHD
6. In Vivo Studies of Fibrotic Mast Cells in Chronic GVHD
7. Future Directions for the Study of Mast Cells in Chronic GVHD
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
Abbreviations
HSCT | Hematopoietic stem cell transplant |
GVHD | Graft-versus-host disease |
aGVHD | Acute graft-versus-host disease |
cGVHD | Chronic graft-versus-host disease |
MC | Mast cell |
allo-HSCT | Allogeneic hematopoietic stem cell transplant |
BOS | Bronchiolitis obliterans syndrome |
Gy | Gray (unit of radiation) |
AEU | Allergic-effector unit |
MHC | Major histocompatibility complex |
miHag | Minor histocompatibility antigen |
allo-WT | Allogeneic transplant—Wild type recipients |
allo-MCd | Allogeneic transplant—Mast cell-deficient recipients |
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Strattan, E.; Hildebrandt, G.C. Mast Cell Involvement in Fibrosis in Chronic Graft-Versus-Host Disease. Int. J. Mol. Sci. 2021, 22, 2385. https://doi.org/10.3390/ijms22052385
Strattan E, Hildebrandt GC. Mast Cell Involvement in Fibrosis in Chronic Graft-Versus-Host Disease. International Journal of Molecular Sciences. 2021; 22(5):2385. https://doi.org/10.3390/ijms22052385
Chicago/Turabian StyleStrattan, Ethan, and Gerhard Carl Hildebrandt. 2021. "Mast Cell Involvement in Fibrosis in Chronic Graft-Versus-Host Disease" International Journal of Molecular Sciences 22, no. 5: 2385. https://doi.org/10.3390/ijms22052385