Glucocorticoid Receptor Antagonist Mifepristone Does Not Alter Innate Anxiety-Like Behavior in Genetically-Selected Marchigian Sardinian (msP) Rats
Abstract
:1. Introduction
2. Results
2.1. Effects of Mifepristone on Anxiety-Like Behavior
2.2. Effects of Mifepristone on Sleep Disturbances
2.3. Effects of Mifepristone on Hyperarousal States
3. Discussion
4. Materials and Methods
4.1. Animals
4.2. Drug Preparation and Treatment
4.3. Novelty-Induced Hypophagia (NIH)
4.4. Comprehensive Lab Animal Monitoring System (CLAMS)
4.5. Acoustic Startle
4.6. Statistical Analyses
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Vozella, V.; Cruz, B.; Natividad, L.A.; Benvenuti, F.; Cannella, N.; Edwards, S.; Zorrilla, E.P.; Ciccocioppo, R.; Roberto, M. Glucocorticoid Receptor Antagonist Mifepristone Does Not Alter Innate Anxiety-Like Behavior in Genetically-Selected Marchigian Sardinian (msP) Rats. Int. J. Mol. Sci. 2021, 22, 3095. https://doi.org/10.3390/ijms22063095
Vozella V, Cruz B, Natividad LA, Benvenuti F, Cannella N, Edwards S, Zorrilla EP, Ciccocioppo R, Roberto M. Glucocorticoid Receptor Antagonist Mifepristone Does Not Alter Innate Anxiety-Like Behavior in Genetically-Selected Marchigian Sardinian (msP) Rats. International Journal of Molecular Sciences. 2021; 22(6):3095. https://doi.org/10.3390/ijms22063095
Chicago/Turabian StyleVozella, Valentina, Bryan Cruz, Luis A. Natividad, Federica Benvenuti, Nazzareno Cannella, Scott Edwards, Eric P. Zorrilla, Roberto Ciccocioppo, and Marisa Roberto. 2021. "Glucocorticoid Receptor Antagonist Mifepristone Does Not Alter Innate Anxiety-Like Behavior in Genetically-Selected Marchigian Sardinian (msP) Rats" International Journal of Molecular Sciences 22, no. 6: 3095. https://doi.org/10.3390/ijms22063095