Sexual Dimorphism in Glucocorticoid Stress Response
Round 1
Reviewer 1 Report
General comment: The review “Sexual dimorphism in glucocorticoid stress response” is interesting and relevant for physiological and clinical applications. This review provide an insight into the most relevant various molecular mechanisms explain sex-specific glucocorticoid stress responses, suggesting an important gender effects in humans.
This study is interesting and suggests that the sexual dimorphism in glucocorticoid stress response could explain the sex bias in stress-related diseases. The paper is clear and well written.
Overall this is an interesting manuscript that provides additional information on sex chromosomes influence about sex-specific biology as soon as conception. The Authors explain how the cerebral regions implicated in glucocorticoid regulation at rest and after stress are thereby impacted in a sex-specific manner.
The subject addressed in this study is worthy of investigation and the information presented was interesting. The discussion is well done and exhaustively compared to up-to-date reported in literature. The conclusions were supported by the original data, interesting and applicative in the field of sexual dimorphism in glucocorticoid stress response.
References are extended and well done.
The review shows suitable descriptions and the references on main topics are appropriate. I consider this review about style, presentation and grammar acceptable and suitable for publication in your journal.
General comment: The review “Sexual dimorphism in glucocorticoid stress response” is interesting and relevant for physiological and clinical applications. This review provide an insight into the most relevant arious molecular mechanisms explain sex-specific glucocorticoid stress responses, suggesting animportant gender effects in humans.
This study is interest and suggest that the sexual dimorphism in glucocorticoid stress response could explain the sex bias in stress-related diseases.
The paper is clear and well written.
Overall this is an interesting manuscript that provides additional information on sex chromosomes influence about sex-specific biology as soon as conception. The Authors explain how the cerebral regions implicated in glucocorticoid regulation at rest and after stress are thereby impacted in a sex-specific manner.
The subject addressed in this study is worthy of investigation and the information presented was interesting. The discussion is well discussed and exhaustively compared to up-to-date reported in literature. The conclusions were supported by the original data, interesting and applicative in the field of sexual dimorphism in glucocorticoid stress response.
References are extended and well done.
The review shows suitable descriptions and the references on main topics are appropriate. I consider this review about style, presentation and grammar acceptable and suitable for publication in your journal.
Reviewer 2 Report
Dear author
Thank you for the work! I have found the Review very useful and interesting. I hope it will be of great interest to the readers as well. Waiting for the manuscript to be published.
Only one minor remark
- line 233 et al (Testosterone acts through AR or through ER@@or ER@after testosterone) Please correct the receptors. There are some strange symbols in the text.
