Interactions between Chemesthesis and Taste: Role of TRPA1 and TRPV1
Abstract
:1. Introduction
2. TRPA1 and TRPV1: Key Chemosensory Ion Channels in Chemesthesis
2.1. TRPA1
2.1.1. TRPA1 Structure, Expression and Function
2.1.2. Plant-Derived TRPA1 Agonists
2.1.3. TRPA1 Activators in Korean Indigenous Plants
2.2. TRPV1
2.2.1. TRPV1 Structure, Expression and Function
2.2.2. TRPV1 and Primary Taste Qualities
3. Potential Role of TRPA1 and TRPV1 as a Bridge between Taste and Chemesthesis
3.1. Cross Talk between TRPA1 and TRPV1
3.2. TRPA1 and TRPV1 as a Bridge between Taste and Chemesthesis
3.3. Chemesthesis and Sour Taste as Co-Mediators of Acid-Evoked Aversion
3.4. Chemesthesis and Bitter Taste as Co-Mediators of Bitter-Evoked Aversion
3.5. Chemesthesis and Salt Taste
3.6. Effect of Single-Nucleotide Polymorphisms in TRPA1 and TRPV1 on Chemesthesis and Taste
4. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
AITC | Allyl isothiocyanate |
CALHM | Calcium homeostasis modulator |
CGRP | Calcitonin generelated peptide |
ENaC | Epithelial Na+ channel |
GNAT3 | Guanine nucleotide-binding protein G(t) subunit alpha-3 |
HEK | Human embryonic kidney |
IP3 | Inositol triphosphate receptor type 3 |
KCNJ2 | Potassium inwardly rectifying channel subfamily J member 2 |
nAChR | Nicotinic acetylcholine receptor |
PKD2L1 | Polycystin 2 like 1 |
PLC | Phospholipase C |
SKN-1a | Transcription factor skinhead-1a |
T1R | Taste receptor type 1 |
T2R | Taste receptor type 2 |
TRP | Transient receptor potential |
TRPA1 | Transient receptor potential ankyrin member 1 |
TRPM5 | Transient receptor potential melastatin member 5 |
TRPV1 | Transient receptor potential vanilloid member 1 |
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English Name | Local Name | Used Part | Taxon | Scientific Name |
---|---|---|---|---|
Edible amaranth | Bireum | Leaf | Amaranthaceae | Amaranthus mangostanus L. |
Devil’s bush | Gasiogalpi | Bark | Araliaceae | Eleutherococcus sessiliflorus (Rupr. & Maxim.) Maxim. |
Prickly castor oil tree | Gaeduleub | Sprout | Araliaceae | Kalopanax septemlobus (Thunb.) Koidz. |
Korean dendranthema | Sangujeolcho | Whole plant | Compositae | Dendranthema zawadskii (Herb) Tzvelev |
Indian lettuce | Wanggodeulppaegi | Leaf | Compositae | Lactuca indica L. |
Fischer’s ragwort | Gomchwi | Leaf | Compositae | Ligularia fischeri (Ledeb.) Turcz. |
Korean dandelion | Mindeulle | Stem & leaf | Compositae | Taraxacum platycarpum Dahlst. |
Wild wasabi | Gochunaengi | Leaf | Cruciferae | Eutrema japonicum (Miq.) Koidz |
Korean mint | Baechohyang | Stem & leaf | Labiatae | Agastache rugosa (Fisch. & Mey.) Kuntze |
Oriental motherwort | Igmocho | Stem & leaf | Labiatae | Leonurus japonicus Houtt. |
Korean wild chive | Dallae | Whole plant | Liliaceae | Allium monanthum Maxim. |
Myeongyi | Ulleungsanmaneul | Leaf | Liliaceae | Allium ochotense Prokh. |
Rocky licorice-root | Gaehoehyang | Whole plant | Umbelliferae | Ligusticum tachiroei (Franch. & Sav.) M.Hiroe & Constance |
Java water-dropwort | Dolminari | Stem & leaf | Umbelliferae | Oenanthe javanica (Blume) DC. |
Kamchatka pleurospermum | Waeusanpul | Stem & leaf | Umbelliferae | Pleurospermum camtschaticum Hoffm. |
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Rhyu, M.-R.; Kim, Y.; Lyall, V. Interactions between Chemesthesis and Taste: Role of TRPA1 and TRPV1. Int. J. Mol. Sci. 2021, 22, 3360. https://doi.org/10.3390/ijms22073360
Rhyu M-R, Kim Y, Lyall V. Interactions between Chemesthesis and Taste: Role of TRPA1 and TRPV1. International Journal of Molecular Sciences. 2021; 22(7):3360. https://doi.org/10.3390/ijms22073360
Chicago/Turabian StyleRhyu, Mee-Ra, Yiseul Kim, and Vijay Lyall. 2021. "Interactions between Chemesthesis and Taste: Role of TRPA1 and TRPV1" International Journal of Molecular Sciences 22, no. 7: 3360. https://doi.org/10.3390/ijms22073360