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Volume 22
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Review

Inflammatory Molecules Associated with Ultraviolet Radiation-Mediated Skin Aging

by
Tuba M. Ansary
,
Md. Razib Hossain
,
Koji Kamiya
,
Mayumi Komine
* and
Mamitaro Ohtsuki
Department of Dermatology, Faculty of Medicine, Jichi Medical University, Tochigi 329-0498, Japan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(8), 3974; https://doi.org/10.3390/ijms22083974
Submission received: 15 March 2021 / Revised: 5 April 2021 / Accepted: 6 April 2021 / Published: 12 April 2021
(This article belongs to the Special Issue Inflammation in Health and Disease: New Insights and Therapeutic Avenues)
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Abstract

Skin is the largest and most complex organ in the human body comprised of multiple layers with different types of cells. Different kinds of environmental stressors, for example, ultraviolet radiation (UVR), temperature, air pollutants, smoking, and diet, accelerate skin aging by stimulating inflammatory molecules. Skin aging caused by UVR is characterized by loss of elasticity, fine lines, wrinkles, reduced epidermal and dermal components, increased epidermal permeability, delayed wound healing, and approximately 90% of skin aging. These external factors can cause aging through reactive oxygen species (ROS)-mediated inflammation, as well as aged skin is a source of circulatory inflammatory molecules which accelerate skin aging and cause aging-related diseases. This review article focuses on the inflammatory pathways associated with UVR-mediated skin aging.
Keywords: inflammation; ultraviolet radiation (UVR); skin aging inflammation; ultraviolet radiation (UVR); skin aging

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MDPI and ACS Style

Ansary, T.M.; Hossain, M.R.; Kamiya, K.; Komine, M.; Ohtsuki, M. Inflammatory Molecules Associated with Ultraviolet Radiation-Mediated Skin Aging. Int. J. Mol. Sci. 2021, 22, 3974. https://doi.org/10.3390/ijms22083974

AMA Style

Ansary TM, Hossain MR, Kamiya K, Komine M, Ohtsuki M. Inflammatory Molecules Associated with Ultraviolet Radiation-Mediated Skin Aging. International Journal of Molecular Sciences. 2021; 22(8):3974. https://doi.org/10.3390/ijms22083974

Chicago/Turabian Style

Ansary, Tuba M., Md. Razib Hossain, Koji Kamiya, Mayumi Komine, and Mamitaro Ohtsuki. 2021. "Inflammatory Molecules Associated with Ultraviolet Radiation-Mediated Skin Aging" International Journal of Molecular Sciences 22, no. 8: 3974. https://doi.org/10.3390/ijms22083974

APA Style

Ansary, T. M., Hossain, M. R., Kamiya, K., Komine, M., & Ohtsuki, M. (2021). Inflammatory Molecules Associated with Ultraviolet Radiation-Mediated Skin Aging. International Journal of Molecular Sciences, 22(8), 3974. https://doi.org/10.3390/ijms22083974

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