Insights into the Functional Role of ADTRP (Androgen-Dependent TFPI-Regulating Protein) in Health and Disease
Abstract
:1. General Introduction
2. Discovery of ADTRP
3. Structure, Expression, and Tissue Localization of ADTRP
4. Cross-Talk between TFPI and ADTRP
4.1. Regulation of ADTRP Expression by Androgen
4.2. Regulation of TFPI Expression by ADTRP
4.3. Functional Significance of ADTRP-TFPI Interactions
4.3.1. ADTRP Regulates the Expression and Activity of Cell-Associated TFPI
4.3.2. ADTRP-TFPI Axis Regulates Myelopoiesis and Hematopoiesis
4.3.3. ADTRP-TFPI Interaction and Hemostasis/Thrombosis Defects
5. Role of ADTRP in Cardiovascular Health and Disease
5.1. rs6903956 in ADTRP Is a Novel Susceptibility Locus for CAD
5.2. ADTRP Up-Regulation May Be Beneficial for Cardiovascular Function
5.3. Role of ADTRP in Vascular Development and Homeostasis
6. Function of ADTRP as an Endogenous Membrane Atypical Hydrolase
7. Role of ADTRP in Stem Cells Differentiation
8. Conclusions and Future Perspectives
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Lupu, C.; Patel, M.M.; Lupu, F. Insights into the Functional Role of ADTRP (Androgen-Dependent TFPI-Regulating Protein) in Health and Disease. Int. J. Mol. Sci. 2021, 22, 4451. https://doi.org/10.3390/ijms22094451
Lupu C, Patel MM, Lupu F. Insights into the Functional Role of ADTRP (Androgen-Dependent TFPI-Regulating Protein) in Health and Disease. International Journal of Molecular Sciences. 2021; 22(9):4451. https://doi.org/10.3390/ijms22094451
Chicago/Turabian StyleLupu, Cristina, Maulin M. Patel, and Florea Lupu. 2021. "Insights into the Functional Role of ADTRP (Androgen-Dependent TFPI-Regulating Protein) in Health and Disease" International Journal of Molecular Sciences 22, no. 9: 4451. https://doi.org/10.3390/ijms22094451