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Volume 22
Issue 9
10.3390/ijms22094874
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Review

Role of Hypoxia in the Control of the Cell Cycle

by
Jimena Druker
1,
James W. Wilson
2,
Fraser Child
2,
Dilem Shakir
2,
Temitope Fasanya
2 and
Sonia Rocha
2,*
1
Centre for Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
2
Department of Molecular Physiology and Cell Signalling, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UK
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(9), 4874; https://doi.org/10.3390/ijms22094874
Submission received: 13 April 2021 / Revised: 2 May 2021 / Accepted: 3 May 2021 / Published: 5 May 2021
(This article belongs to the Special Issue Transcriptional Regulation, Chromatin Structure Changes and Cell Cycle Control in Hypoxia)
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Abstract

The cell cycle is an important cellular process whereby the cell attempts to replicate its genome in an error-free manner. As such, mechanisms must exist for the cell cycle to respond to stress signals such as those elicited by hypoxia or reduced oxygen availability. This review focuses on the role of transcriptional and post-transcriptional mechanisms initiated in hypoxia that interface with cell cycle control. In addition, we discuss how the cell cycle can alter the hypoxia response. Overall, the cellular response to hypoxia and the cell cycle are linked through a variety of mechanisms, allowing cells to respond to hypoxia in a manner that ensures survival and minimal errors throughout cell division.
Keywords: hypoxia; cell cycle; HIF; PHDs; 2-OGDs; mitosis hypoxia; cell cycle; HIF; PHDs; 2-OGDs; mitosis

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MDPI and ACS Style

Druker, J.; Wilson, J.W.; Child, F.; Shakir, D.; Fasanya, T.; Rocha, S. Role of Hypoxia in the Control of the Cell Cycle. Int. J. Mol. Sci. 2021, 22, 4874. https://doi.org/10.3390/ijms22094874

AMA Style

Druker J, Wilson JW, Child F, Shakir D, Fasanya T, Rocha S. Role of Hypoxia in the Control of the Cell Cycle. International Journal of Molecular Sciences. 2021; 22(9):4874. https://doi.org/10.3390/ijms22094874

Chicago/Turabian Style

Druker, Jimena, James W. Wilson, Fraser Child, Dilem Shakir, Temitope Fasanya, and Sonia Rocha. 2021. "Role of Hypoxia in the Control of the Cell Cycle" International Journal of Molecular Sciences 22, no. 9: 4874. https://doi.org/10.3390/ijms22094874

APA Style

Druker, J., Wilson, J. W., Child, F., Shakir, D., Fasanya, T., & Rocha, S. (2021). Role of Hypoxia in the Control of the Cell Cycle. International Journal of Molecular Sciences, 22(9), 4874. https://doi.org/10.3390/ijms22094874

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