A Review on the Role of miR-149-5p in the Carcinogenesis

Ghafouri-Fard, Soudeh; Khoshbakht, Tayyebeh; Hussen, Bashdar Mahmud; Kadkhoda, Sepideh; Taheri, Mohammad; Tafrishinejad, Arash

doi:10.3390/ijms23010415

Open AccessReview

A Review on the Role of miR-149-5p in the Carcinogenesis

by

Soudeh Ghafouri-Fard

¹

,

Tayyebeh Khoshbakht

²,

Bashdar Mahmud Hussen

³

,

Sepideh Kadkhoda

⁴,

Mohammad Taheri

^5,* and

Arash Tafrishinejad

^6,*

¹

Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran 16666-63111, Iran

²

Men’s Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran 16666-63111, Iran

³

Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Kurdistan Region, Erbil 44001, Iraq

⁴

Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran 16666-63111, Iran

⁵

Institute of Human Genetics, Jena University Hospital, 07740 Jena, Germany

⁶

Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran 16666-63111, Iran

^*

Authors to whom correspondence should be addressed.

Int. J. Mol. Sci. 2022, 23(1), 415; https://doi.org/10.3390/ijms23010415

Submission received: 29 November 2021 / Revised: 28 December 2021 / Accepted: 29 December 2021 / Published: 30 December 2021

(This article belongs to the Special Issue Regulation by Non-coding RNAs 2022)

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Abstract

miR-149 is an miRNA with essential roles in carcinogenesis. This miRNA is encoded by the MIR149 gene on 2q37.3. The miR-149 hairpin produces miR-149-5p and miR-149-3p, which are the “guide” and the sister “passenger” strands, respectively. Deep sequencing experiments have shown higher prevalence of miR-149-5p compared with miR-149-3p. Notably, both oncogenic and tumor suppressive roles have been reported for miR-149-5p. In this review, we summarize the impact of miR-149-5p in the tumorigenesis and elaborate mechanisms of its involvement in this process in a variety of neoplastic conditions based on three lines of evidence, i.e., in vitro, in vivo and clinical settings.

Keywords: miR-149-5p; cancer; biomarker; expression; ncRNAs

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MDPI and ACS Style

Ghafouri-Fard, S.; Khoshbakht, T.; Hussen, B.M.; Kadkhoda, S.; Taheri, M.; Tafrishinejad, A. A Review on the Role of miR-149-5p in the Carcinogenesis. Int. J. Mol. Sci. 2022, 23, 415. https://doi.org/10.3390/ijms23010415

AMA Style

Ghafouri-Fard S, Khoshbakht T, Hussen BM, Kadkhoda S, Taheri M, Tafrishinejad A. A Review on the Role of miR-149-5p in the Carcinogenesis. International Journal of Molecular Sciences. 2022; 23(1):415. https://doi.org/10.3390/ijms23010415

Chicago/Turabian Style

Ghafouri-Fard, Soudeh, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Sepideh Kadkhoda, Mohammad Taheri, and Arash Tafrishinejad. 2022. "A Review on the Role of miR-149-5p in the Carcinogenesis" International Journal of Molecular Sciences 23, no. 1: 415. https://doi.org/10.3390/ijms23010415

APA Style

Ghafouri-Fard, S., Khoshbakht, T., Hussen, B. M., Kadkhoda, S., Taheri, M., & Tafrishinejad, A. (2022). A Review on the Role of miR-149-5p in the Carcinogenesis. International Journal of Molecular Sciences, 23(1), 415. https://doi.org/10.3390/ijms23010415

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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A Review on the Role of miR-149-5p in the Carcinogenesis

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