MiR-155: An Important Regulator of Neuroinflammation
Abstract
:1. Introduction
2. MiRNAs
3. Neuroinflammation
4. MiR-155
4.1. MiR-155 and Alzheimer’s Disease
4.2. MiR-155 and Multiple Sclerosis
4.3. MiR-155 in Other Neuroinflammatory Disorders
4.3.1. Parkinson’s Disease
4.3.2. Ischemic Stroke
4.3.3. Amyotrophic Lateral Sclerosis
4.3.4. Traumatic Brain Injuries
4.3.5. Neuroinflammation Induced by Viral Infections
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Acknowledgments
Conflicts of Interest
Abbreviations
ABL | Acetylbritannilactone |
AD | Alzheimer’s disease |
AGO-2 | Argonaute 2 |
ALS | Amyotrophic lateral sclerosis; |
ANXA-2 | Annexin-2 |
Aβ | Beta-amyloid peptide |
BACE1 | β-site APP cleaving enzyme |
BACH1 | BTB Domain And CNC Homolog 1 |
BBB | Blood–brain barrier |
BDMs | Blood-derived monocytes |
CAPE | Caffeic acid phenethyl ester |
CAY10512 | 1-fluoro-2-[2-(4-methoxyphenyl)-ethenyl]-benzene |
CFH | Complement factor H |
CLDN-1 | Claudin-1 |
CNS | Central nervous system |
CSF | Cerebrospinal fluid |
CXCL10 | C-X-C Motif Chemokine Ligand 10 |
DGCR8 | DiGeorge Syndrome Critical Region Gene 8 |
DMF | Dimethylfumarate |
DOCK-1 | Dedicator of cytokinesis 1 |
EAE | Experimental autoimmune encephalomyelitis |
ECF | Extracellular fluid |
ECM | Extracellular matrix |
EMVs | Endothelial microvesicles |
GA | Glatiramer acetate |
GLGZD | GualouGuizhi decoction |
H2S | Hydrogen sulfide |
HIV | Human immunodeficiency virus |
HNG | Human neuronal–glial |
HSE | Herpes simplex encephalitis |
HSV | Herpes simplex virus |
JHMV | strain of mouse hepatitis virus |
IFN | Interferon |
IL | Interleukin |
IL13Rα1 | Interleukin 13 receptor alpha 1 |
iNOS | Inducible nitric oxide synthase |
IRF8 | Interferon regulatory factor 8 |
IS | Ischemic ictus |
JAK | Janus tyrosine kinase |
JEV | Japanese encephalitis virus |
KO | Knockout |
LPS | Lipopolysaccharide |
M1 | Pro-inflammatoryphenotype |
M2 | Anti-inflammatoryphenotype |
MDMs | Monocyte-derived macrophages |
MMP-9 | Matrix metalloproteinase |
MOG | Myelin-oligodendrocyte glycoprotein |
MPs | Microparticles |
MS | Multiple sclerosis |
MSC | Mesenchymal stem cells |
NDsEV | Extracellular vesicles derived from |
NF-κB | Nuclear factor κB |
NO | Nitric oxide |
NVU | Neurovascular unit |
p53 | Tumor protein P53 |
PBMC | Peripheral blood mononuclear cells |
PD | Parkinson’s disease |
PI3K | Phosphoinositide 3-kinase |
PPMS | Primary progressive multiple sclerosis |
RA | Rosmarinic acid |
RISC | RNA-Induced Silencing Complex |
ROS | Reactive oxygen species |
RRMS | Relapsing-remitting multiple sclerosis |
SAMHD1 | Sterile alpha motif and histidine/aspartic acid domain-containing protein 1 |
SDCBP | Syntenin-1 |
SHIP1 | SH2 Domain-Containing Inositol 5′-Phosphatase1 |
SNPs | Single nucleotide polymorphisms |
SOCS1 | Suppressor of cytokine signaling |
SPMS | Secondary progressive multiple sclerosis |
STAT | Signal transducer and activator of transcription |
p-STAT1 | Phosphorylated-Signal Transducers and Activators of Transcription |
TBI | Traumatic brain injury |
TBK-1 | TANK-binding kinase 1 |
TGF-β | Transforming Growth Factor β |
TLRs | Toll-like receptors |
TNF-α | Tumor necrosis factor |
TRBP | TAR RNA binding protein |
WNV | West Nile virus |
WT | Wild-type |
α-syn | α-synuclein |
ZIKV | Zika virus |
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Model/Cell Type | Expression of MiR-155 | Results | References |
---|---|---|---|
LPS-stimulated microglia cells | Up | <Aβ42 catabolism | [57] |
BDMs and MDMs of AD | Up | activation status M1 | [58] |
ECF and CSF of AD patients HNG cells | Up | induction inflammatory gene expression | [59] |
HNG cells | Up | CAPE and CAY10512 agents: <miR-155 | [60] |
APPtg and TAUtg mice | Up | AD genes correlation | [61] |
SAMP8 mice | Up | AD genes correlation | [62] |
Model 3xTg AD N9 microglia cells Astrocyte | Up | activation of microglia and astrocytes <SOCS-1 <MiR-155 after treatment with siRNA c-Jun | [63] |
ApoE3-5xFAD mice | Up | Curcumin: <miR-155 | [64] |
Wistar rats/LPS | Up | H2S and MSC: <miR-155 | [65] |
Rat hippocampus AD | Up | Anti-miR-155: <IL-1β, IL-6, TNF-α <cognitive impairment | [66] |
Model/Cell Type | Expression of MiR-155 | Results | References |
---|---|---|---|
serum and plasma of MS patients | Up | - | [73] |
PBMC of MS patients | Up | - | [74] |
lesions of MS | Up | inhibition CD47 | [75] |
CD14+ and CD68+ of MS patients | Up | anti-miR-155: <inflammatory cytokines | [76] |
EAE | Up | Anti-miR-155: <IFN-γ > IL-4 | [77] |
EAE | Up | anti-miR-155: <clinical severity | [78] |
EAE MS patients | Up | >Th1 and Th17 cells | [79] |
EAE miR-155−/− cells | - | <Th17 cells | [80] |
EAE MS patients | Up | >BBB permeability | [81] |
MS patients | Up | DMF treatment: <miR-55 | [82,83] |
MS patients | Up | Natalizumab treatment: <miR-155 | [84] |
MS patients | Up | GA treatment: <miR-155 | [85] |
Disorder | Model/Cell Type | Expression of MiR-155 | Results | References |
---|---|---|---|---|
PD | PBMC of PD patients | up | - | [87] |
NDsEV | up | - | [88] | |
Microglia/astrocyte | up | <SOCS | [89] | |
PD’s model | - | miR-155-5p agomir: <efficacy RA >inflammation microglia activation | [90] | |
PD’s model MiR-155 −/− | - | <proinflammatory signaling Blockage neurodegeneration | [91] | |
IS | CD1 and C57/BL6 mice with MCAO | up | Correlation miR-155/ABL | [92] |
Serum of IS patients | up | >JAK2/STAT3 >TNF-α | [93] | |
EMVs | up | >infarct volume | [94] | |
HT22 and BV2 cells | up | GLGZD treatment: <miR-155 <TNF-α, IL6 and IFN-γ | [95] | |
MCAO rat | up | GLGZD treatment: <miR-155 <SOCS1 | [96] | |
MCAO C57BL/6 mice | up | anti-miR-155: <pro-inflammatory cytokines | [97] | |
MCAO C57BL/6 mice | up | anti-miR-155: <damage | [98] | |
ALS | mice SOD1G93A | up | anti-miR-155: restored dysfunctional microglia | [99] |
mice SOD1G93A | up | anti-miR-155: >38% survival | [100] |
Model/Cell Type | Expression of MiR-155 | Results | References |
---|---|---|---|
Serum of TBI mice | Up | - | [110] |
Mitochondria and cytosolic hippocampal fractions of TBI rats | Up | - | [111] |
Cytoplasm and mitochondria | Up | - | [112] |
CCI model induced in C57BL/6 mice and MiR-155 KO | Up | MiR-155 KO: <type I interferons >Iba1 | [113] |
CCI C57Bl/6J mice | Up | <SOCS1 anti-miR-155: <neuroinflammation | [114] |
CCI Long Evans rats | Up | Mitochondrial dysfunction | [115] |
CD11b+ cells | Up | - | [116] |
CCI C57BL/6 mice; BV2 cells treated with LPS | Up | Microglia isolated MP contained miR-155 and propagate inflammation | [117] |
Intestinal mucosa TBI patients | Up | <CLDN-1 intestinal mucosa dysfunction | [118] |
TBI Wistar rats | - | Formononetin increased miR-155 | [119] |
LPS-treated BV2 cells | - | Propofol reduced miR-155 | [120] |
Model/Cell Type | Expression of MiR-155 | Results | References |
---|---|---|---|
HSV-1 mice | Up | - | [122] |
miR-155−/− mice | - | >susceptible to HSE | [123] |
JHMV miR-155−/− mice | Up - | - elevated morbidity and mortality rate <T CD8+ | [124] |
WNV miR-155−/− mice | Up - | - miR-155−/− mice: >high virus titer >IFN-α | [125] |
BV-2 and mice BALB/c with JEV | Up | <SHIP1 anti-miR-155: <IFN-β, pro-inflammatory cytokines | [126] |
CHME3 cells infected with JEV | Up | <viral replication >CD45 <p-STAT1 | [127] |
ZIKV | Up | - | [128] |
LCMV-infected mice | - | Regulation of SOCS1 | [129] |
HIV-infected astrocytes | - | Regulation of SAMHD1 | [130] |
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Zingale, V.D.; Gugliandolo, A.; Mazzon, E. MiR-155: An Important Regulator of Neuroinflammation. Int. J. Mol. Sci. 2022, 23, 90. https://doi.org/10.3390/ijms23010090
Zingale VD, Gugliandolo A, Mazzon E. MiR-155: An Important Regulator of Neuroinflammation. International Journal of Molecular Sciences. 2022; 23(1):90. https://doi.org/10.3390/ijms23010090
Chicago/Turabian StyleZingale, Valeria Domenica, Agnese Gugliandolo, and Emanuela Mazzon. 2022. "MiR-155: An Important Regulator of Neuroinflammation" International Journal of Molecular Sciences 23, no. 1: 90. https://doi.org/10.3390/ijms23010090