MicroPET Imaging Assessment of Brain Tau and Amyloid Deposition in 6 × Tg Alzheimer’s Disease Model Mice
Abstract
:1. Introduction
2. Results
2.1. In Vivo Amyloid, Inflammation and Tau PET Imaging of 6 × Tg Model Mice
2.2. In Vivo [18F]Flutemetamol PET Imaging Detected Aging-Related and AD-Associated Elevation in Brain Aβ
2.3. In Vivo [18F]DPA714 PET Imaging Detected AD-Associated Inflammation in the Brain
2.4. In Vivo [18F]THK5351 and [18F]MK6240 PET Imaging Detected AD-Associated Elevation in Brain Tau
3. Discussion
4. Materials and Methods
4.1. Animals
4.2. MicroPET Studies
4.3. Immunohistochemistry
4.4. ELISA
4.5. Western Blot
4.6. Statistical Analysis
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Kang, S.; Kim, J.; Lee, S.-Y.; Okamura, N.; Chang, K.-A. MicroPET Imaging Assessment of Brain Tau and Amyloid Deposition in 6 × Tg Alzheimer’s Disease Model Mice. Int. J. Mol. Sci. 2022, 23, 5485. https://doi.org/10.3390/ijms23105485
Kang S, Kim J, Lee S-Y, Okamura N, Chang K-A. MicroPET Imaging Assessment of Brain Tau and Amyloid Deposition in 6 × Tg Alzheimer’s Disease Model Mice. International Journal of Molecular Sciences. 2022; 23(10):5485. https://doi.org/10.3390/ijms23105485
Chicago/Turabian StyleKang, ShinWoo, Jinho Kim, Sang-Yoon Lee, Nobuyuki Okamura, and Keun-A Chang. 2022. "MicroPET Imaging Assessment of Brain Tau and Amyloid Deposition in 6 × Tg Alzheimer’s Disease Model Mice" International Journal of Molecular Sciences 23, no. 10: 5485. https://doi.org/10.3390/ijms23105485