Thalidomide Alleviates Pulmonary Fibrosis Induced by Silica in Mice by Inhibiting ER Stress and the TLR4-NF-κB Pathway
, Wenchen Cai †, Fuyu Jin, Xiaojing Wang, Wenjing Liu, Tian Li, Xinyu Yang, Heliang Liu, Hong Xu * and Fang Yang *
Round 1
Reviewer 1 Report
The manuscript “Thalidomide Alleviates Pulmonary Fibrosis Induced by Silica in Mice by Inhibiting ER Stress and the TLR4-NF-κB Pathway” by Yaqian Li et al. They have; reported that Thalidomide effectively attenuates silica-induced pulmonary inflammation and fibrosis in mice and MH-S cells model. The manuscript is written in good English language with few grammatical errors. I have just a few minor concerns.
Comments:
- The authors should check grammatical errors very carefully before resubmission.
- Resolution of figure labels of 2 E-H, 3C-E, 4B-K, 5A-M, 6B-F, and 7B-M are poor and must be improved
Author Response
Please see the attachment
Author Response File: 
Author Response.pdf
Reviewer 2 Report
This is a well done study. The questions posed by the authors have been convincingly proven experimentally.
I have no serious comments. But there are a few wishes.
1. The quality of the figures needs to be improved. Enlarge diagrams as they are difficult to read.
2. Since the authors are talking about the mechanism, I recommend preparing an intracellular signaling scheme at the end of the article.
3. The work should be carefully re-read, because there are small errors, extra commas, etc.
Author Response
Please see the attachment
Author Response File: Author Response.pdf
