In Vivo Dynamic Movement of Polymerized Amyloid β in the Perivascular Space of the Cerebral Cortex in Mice
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animal Preparation
2.2. Aβ and Dextran Solutions
2.3. In Vivo Observation with Two-Photon Microscopy
2.4. Statistical Analysis
3. Results
3.1. Fibril Formation of Aβ1–40
3.2. Perivascular Distribution of Aβ1–40
3.3. Dynamic Perivascular Transportation of Aβ
3.4. Capillary Accumulation of Aβ in the Parenchyma
3.5. Perivascular Flow of Large Dextran
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Acknowledgments
Conflicts of Interest
References
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Hasegawa, I.; Hirayoshi, Y.; Minatani, S.; Mino, T.; Takeda, A.; Itoh, Y. In Vivo Dynamic Movement of Polymerized Amyloid β in the Perivascular Space of the Cerebral Cortex in Mice. Int. J. Mol. Sci. 2022, 23, 6422. https://doi.org/10.3390/ijms23126422
Hasegawa I, Hirayoshi Y, Minatani S, Mino T, Takeda A, Itoh Y. In Vivo Dynamic Movement of Polymerized Amyloid β in the Perivascular Space of the Cerebral Cortex in Mice. International Journal of Molecular Sciences. 2022; 23(12):6422. https://doi.org/10.3390/ijms23126422
Chicago/Turabian StyleHasegawa, Itsuki, Yoko Hirayoshi, Shinobu Minatani, Toshikazu Mino, Akitoshi Takeda, and Yoshiaki Itoh. 2022. "In Vivo Dynamic Movement of Polymerized Amyloid β in the Perivascular Space of the Cerebral Cortex in Mice" International Journal of Molecular Sciences 23, no. 12: 6422. https://doi.org/10.3390/ijms23126422