Decoding the Effect of Hydrostatic Pressure on TRPV1 Lower-Gate Conformation by Molecular-Dynamics Simulation
Abstract
:1. Introduction
2. Materials and Methods
2.1. MD Simulation Setup
2.2. Root Mean Square Deviation (RMSD) Analysis
2.3. Radius of Gyration Analysis
2.4. Radius Analysis
2.5. Statistical Analysis
3. Results
3.1. RMSD
3.2. Radius of Gyration
3.3. Radius of Lower Gate
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Zamri, M.H.B.; Ujihara, Y.; Nakamura, M.; Mofrad, M.R.K.; Sugita, S. Decoding the Effect of Hydrostatic Pressure on TRPV1 Lower-Gate Conformation by Molecular-Dynamics Simulation. Int. J. Mol. Sci. 2022, 23, 7366. https://doi.org/10.3390/ijms23137366
Zamri MHB, Ujihara Y, Nakamura M, Mofrad MRK, Sugita S. Decoding the Effect of Hydrostatic Pressure on TRPV1 Lower-Gate Conformation by Molecular-Dynamics Simulation. International Journal of Molecular Sciences. 2022; 23(13):7366. https://doi.org/10.3390/ijms23137366
Chicago/Turabian StyleZamri, Muhammad Harith Bin, Yoshihiro Ujihara, Masanori Nakamura, Mohammad R. K. Mofrad, and Shukei Sugita. 2022. "Decoding the Effect of Hydrostatic Pressure on TRPV1 Lower-Gate Conformation by Molecular-Dynamics Simulation" International Journal of Molecular Sciences 23, no. 13: 7366. https://doi.org/10.3390/ijms23137366