Molecular Modelling of NONO and SFPQ Dimerization Process and RNA Recognition Mechanism
Abstract
:1. Introduction
2. Results and Discussion
2.1. Comparison of NONO and SFPQ Dimer Stability
2.2. NONO and SFPQ Dimers Have Different Interaction Patterns
2.3. Analysis of NONO and SFPQ Dimer Interactions with RNA
3. Materials and Methods
3.1. Structure Preparation
3.2. Molecular Dynamics (MD)
3.3. Interactions Analysis
3.4. Dimer Formation Energy Calculation
3.5. In Silico Alanine Scan
3.6. DBS::PolyG Model Construction
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
References
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Laurenzi, T.; Palazzolo, L.; Taiana, E.; Saporiti, S.; Ben Mariem, O.; Guerrini, U.; Neri, A.; Eberini, I. Molecular Modelling of NONO and SFPQ Dimerization Process and RNA Recognition Mechanism. Int. J. Mol. Sci. 2022, 23, 7626. https://doi.org/10.3390/ijms23147626
Laurenzi T, Palazzolo L, Taiana E, Saporiti S, Ben Mariem O, Guerrini U, Neri A, Eberini I. Molecular Modelling of NONO and SFPQ Dimerization Process and RNA Recognition Mechanism. International Journal of Molecular Sciences. 2022; 23(14):7626. https://doi.org/10.3390/ijms23147626
Chicago/Turabian StyleLaurenzi, Tommaso, Luca Palazzolo, Elisa Taiana, Simona Saporiti, Omar Ben Mariem, Uliano Guerrini, Antonino Neri, and Ivano Eberini. 2022. "Molecular Modelling of NONO and SFPQ Dimerization Process and RNA Recognition Mechanism" International Journal of Molecular Sciences 23, no. 14: 7626. https://doi.org/10.3390/ijms23147626