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Volume 23
Issue 14
10.3390/ijms23147804
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Article

MicroRNAs as Potential Biomarkers in the Differential Diagnosis of Lipomatous Tumors and Their Mimics

by
Hui Min Tan
1,
He Cheng
2,
Yew Chung Tang
2,
Sai Mun Leong
3,
Poh Yin Teo
4,
Chi Kuen Lee
3,
Victor Kwan Min Lee
1,3 and
Susan Swee-Shan Hue
1,3,5,*
1
Department of Pathology, National University Hospital, National University Health System, Singapore 119074, Singapore
2
MiRXES Lab, Singapore 138623, Singapore
3
Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore
4
Division of Oncology Pharmacy, National University Cancer Institute Singapore, National University Health System, Singapore 119074, Singapore
5
Advanced Molecular Pathology Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore 138673, Singapore
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2022, 23(14), 7804; https://doi.org/10.3390/ijms23147804
Submission received: 17 June 2022 / Revised: 9 July 2022 / Accepted: 13 July 2022 / Published: 15 July 2022
(This article belongs to the Special Issue Novel Insights into Soft Tissue Sarcoma)
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Abstract

Adipocytic tumors are the most common subtype of soft tissue tumors. In current clinical practice, distinguishing benign lipomas from well-differentiated liposarcomas (WDLPS), as well as dedifferentiated liposarcomas (DDLPS) from their morphologic mimics, remains a significant diagnostic challenge. This is especially so when examining small biopsy samples and without the aid of additional ancillary tests. Recognizing the important role that microRNAs (miRNAs) play in tumorigenesis and their potential utility in tumor classification, we analyzed routine clinical tissue samples of benign and malignant lipomatous tumors, as well as other sarcoma mimics, to identify distinguishing miRNA-based signatures that can aid in the differential diagnosis of these entities. We discovered a 6-miRNA signature that separated lipomas from WDLPS with high confidence (AUC of 0.963), as well as a separate 6-miRNA signature that distinguished DDLPS from their more aggressive histologic mimics (AUC of 0.740). Functional enrichment analysis unveiled possible mechanistic involvement of these predictive miRNAs in adipocytic cancer-related biological processes and pathways such as PI3K/AKT/mTOR and MAPK signaling, further supporting the relevance of these miRNAs as biomarkers for adipocytic tumors. Our results demonstrate that miRNA expression profiling may potentially be used as an adjunctive tool for the diagnosis of benign and malignant adipocytic tumors. Further validation studies are warranted.
Keywords: microRNA; lipoma; well-differentiated liposarcoma; dedifferentiated liposarcoma; undifferentiated pleomorphic sarcoma microRNA; lipoma; well-differentiated liposarcoma; dedifferentiated liposarcoma; undifferentiated pleomorphic sarcoma

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MDPI and ACS Style

Tan, H.M.; Cheng, H.; Tang, Y.C.; Leong, S.M.; Teo, P.Y.; Lee, C.K.; Lee, V.K.M.; Hue, S.S.-S. MicroRNAs as Potential Biomarkers in the Differential Diagnosis of Lipomatous Tumors and Their Mimics. Int. J. Mol. Sci. 2022, 23, 7804. https://doi.org/10.3390/ijms23147804

AMA Style

Tan HM, Cheng H, Tang YC, Leong SM, Teo PY, Lee CK, Lee VKM, Hue SS-S. MicroRNAs as Potential Biomarkers in the Differential Diagnosis of Lipomatous Tumors and Their Mimics. International Journal of Molecular Sciences. 2022; 23(14):7804. https://doi.org/10.3390/ijms23147804

Chicago/Turabian Style

Tan, Hui Min, He Cheng, Yew Chung Tang, Sai Mun Leong, Poh Yin Teo, Chi Kuen Lee, Victor Kwan Min Lee, and Susan Swee-Shan Hue. 2022. "MicroRNAs as Potential Biomarkers in the Differential Diagnosis of Lipomatous Tumors and Their Mimics" International Journal of Molecular Sciences 23, no. 14: 7804. https://doi.org/10.3390/ijms23147804

APA Style

Tan, H. M., Cheng, H., Tang, Y. C., Leong, S. M., Teo, P. Y., Lee, C. K., Lee, V. K. M., & Hue, S. S.-S. (2022). MicroRNAs as Potential Biomarkers in the Differential Diagnosis of Lipomatous Tumors and Their Mimics. International Journal of Molecular Sciences, 23(14), 7804. https://doi.org/10.3390/ijms23147804

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