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Review

C-Reactive Protein Velocity (CRPv) as a New Biomarker for the Early Detection of Acute Infection/Inflammation

1
Department of Internal Medicine “E”, Tel Aviv Sourasky Medical Center, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6423906, Israel
2
Infectious Diseases Unit, Tel Aviv Sourasky Medical Center, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6423906, Israel
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2022, 23(15), 8100; https://doi.org/10.3390/ijms23158100
Submission received: 20 June 2022 / Revised: 17 July 2022 / Accepted: 19 July 2022 / Published: 22 July 2022
(This article belongs to the Special Issue Regulation of Inflammatory Reactions in Health and Disease 2.0)

Abstract

C-reactive protein (CRP) is considered a biomarker of infection/inflammation. It is a commonly used tool for early detection of infection in the emergency room or as a point-of-care test and especially for differentiating between bacterial and viral infections, affecting decisions of admission and initiation of antibiotic treatments. As C-reactive protein is part of a dynamic and continuous inflammatory process, a single CRP measurement, especially at low concentrations, may erroneously lead to a wrong classification of an infection as viral over bacterial and delay appropriate antibiotic treatment. In the present review, we introduce the concept of C-reactive protein dynamics, measuring the velocity of C-reactive protein elevation, as a tool to increase this biomarker’s diagnostic ability. We review the studies that helped define new metrics such as estimated C-reactive protein velocity (velocity of C-reactive protein elevation from symptoms’ onset to first C-reactive protein measurement) and the measured C-reactive protein velocity (velocity between sequential C-reactive protein measurements) and the use of these metrics in different clinical scenarios. We also discuss future research directions for this novel metric.
Keywords: C-reactive protein; velocity; inflammation; infection; bacterial; viral C-reactive protein; velocity; inflammation; infection; bacterial; viral

Share and Cite

MDPI and ACS Style

Levinson, T.; Wasserman, A. C-Reactive Protein Velocity (CRPv) as a New Biomarker for the Early Detection of Acute Infection/Inflammation. Int. J. Mol. Sci. 2022, 23, 8100. https://doi.org/10.3390/ijms23158100

AMA Style

Levinson T, Wasserman A. C-Reactive Protein Velocity (CRPv) as a New Biomarker for the Early Detection of Acute Infection/Inflammation. International Journal of Molecular Sciences. 2022; 23(15):8100. https://doi.org/10.3390/ijms23158100

Chicago/Turabian Style

Levinson, Tal, and Asaf Wasserman. 2022. "C-Reactive Protein Velocity (CRPv) as a New Biomarker for the Early Detection of Acute Infection/Inflammation" International Journal of Molecular Sciences 23, no. 15: 8100. https://doi.org/10.3390/ijms23158100

APA Style

Levinson, T., & Wasserman, A. (2022). C-Reactive Protein Velocity (CRPv) as a New Biomarker for the Early Detection of Acute Infection/Inflammation. International Journal of Molecular Sciences, 23(15), 8100. https://doi.org/10.3390/ijms23158100

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