Regulation of CD4+ and CD8+ T Cell Biology by Short-Chain Fatty Acids and Its Relevance for Autoimmune Pathology
, Sharmili Edwin Thanarajah 1, Mareike Aichholzer 1, Silke Matura 1, Andreas Reif 1, Elske Vrieze 2, Andreas Weigert 3 and Alexander Visekruna 4
Round 1
Reviewer 1 Report
Congratulations on the study conducted, the paper is well written and with a good representation of the pathologies associated with SCFA, the only note I would have added talking about the intestinal microbiota is linked to cardiovascular pathologies as there are parameters such as TMAO that are produced by the same. microbiota in relation to the inflammatory state could be useful on the whole to have a situation linked to pathological factors. This is not a criticism but a cue for colleagues to investigate other factors that could be connected to each other. Therefore my opinion on this paper is very positive.
Reviewer 2 Report
The manuscript by Schiweck et al have thoroughly reviewed the effect of short chain fatty acids on the regulation of CD8 and T helper cells in autoimmune diseases. The article is very written well and is an excellent contribution to the field. I would recommend publication of this article in IJMS.
