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Volume 23
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10.3390/ijms23169164
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Communication

Anti-Inflammatory Effects of 1,25(OH)2D/Calcitriol in T Cell Immunity: Does Sex Make a Difference?

by
Daniela Peruzzu
†,
Maria Luisa Dupuis
†,
Marina Pierdominici
,
Katia Fecchi
,
Maria Cristina Gagliardi
,
Elena Ortona
* and
Maria Teresa Pagano
Center for Gender Specific Medicine, Istituto Superiore di Sanità, 00165 Rome, Italy
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2022, 23(16), 9164; https://doi.org/10.3390/ijms23169164
Submission received: 26 July 2022 / Revised: 9 August 2022 / Accepted: 11 August 2022 / Published: 15 August 2022
(This article belongs to the Special Issue The Role of Vitamin D in Human Health and Diseases 2.0)
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Abstract

Hypovitaminosis D is involved in various inflammatory, infectious and autoimmune diseases such as rheumatoid arthritis and multiple sclerosis. Moreover, the active form of vitamin D, calcitriol, has been shown to modulate the immune response, playing an anti-inflammatory effect. However little is known about the mechanisms underlying this anti-inflammatory effect and the potential sex differences of calcitriol immune regulation. Hence, the aim of this study was to investigate whether calcitriol could act differently in modulating T cell immunity of age-matched male and female healthy donors. We analyzed the effects of calcitriol in T lymphocytes from healthy women and men on the expression levels of the vitamin D receptor (VDR) and pro- and anti-inflammatory cytokine production. We showed that a treatment with calcitriol induced a significant increase in the VDR expression levels of activated T lymphocytes from male and female healthy subjects. Moreover, we found that calcitriol significantly reduced the expression level of pro-inflammatory cytokines IL-17, INF-γ and TNF-α in the T lymphocytes of both sexes. Notably, we observed that calcitriol induced a significant increase in the expression level of anti-inflammatory cytokine IL-10 only in the T lymphocytes from female healthy donors. In conclusion, our study provides new insights regarding the sex-specific anti-inflammatory role of calcitriol in T cell immunity.
Keywords: vitamin D; sex hormones; gender; gender difference vitamin D; sex hormones; gender; gender difference

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MDPI and ACS Style

Peruzzu, D.; Dupuis, M.L.; Pierdominici, M.; Fecchi, K.; Gagliardi, M.C.; Ortona, E.; Pagano, M.T. Anti-Inflammatory Effects of 1,25(OH)2D/Calcitriol in T Cell Immunity: Does Sex Make a Difference? Int. J. Mol. Sci. 2022, 23, 9164. https://doi.org/10.3390/ijms23169164

AMA Style

Peruzzu D, Dupuis ML, Pierdominici M, Fecchi K, Gagliardi MC, Ortona E, Pagano MT. Anti-Inflammatory Effects of 1,25(OH)2D/Calcitriol in T Cell Immunity: Does Sex Make a Difference? International Journal of Molecular Sciences. 2022; 23(16):9164. https://doi.org/10.3390/ijms23169164

Chicago/Turabian Style

Peruzzu, Daniela, Maria Luisa Dupuis, Marina Pierdominici, Katia Fecchi, Maria Cristina Gagliardi, Elena Ortona, and Maria Teresa Pagano. 2022. "Anti-Inflammatory Effects of 1,25(OH)2D/Calcitriol in T Cell Immunity: Does Sex Make a Difference?" International Journal of Molecular Sciences 23, no. 16: 9164. https://doi.org/10.3390/ijms23169164

APA Style

Peruzzu, D., Dupuis, M. L., Pierdominici, M., Fecchi, K., Gagliardi, M. C., Ortona, E., & Pagano, M. T. (2022). Anti-Inflammatory Effects of 1,25(OH)2D/Calcitriol in T Cell Immunity: Does Sex Make a Difference? International Journal of Molecular Sciences, 23(16), 9164. https://doi.org/10.3390/ijms23169164

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