Polygenic Risk of Hypertriglyceridemia Is Modified by BMI
Abstract
:1. Introduction
2. Results
3. Discussion
4. Materials and Methods
4.1. Population Selection
4.2. Variables Selected
4.3. Biochemical Analyses
4.4. Genetic Testing
4.5. Selecting SNPs and Development of the Genetic Risk Score
4.6. Statistical Analysis
5. Conclusions
6. Patents
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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CLINICAL VARIABLES | Total | GRS | p | |
---|---|---|---|---|
n = 276 | ≤6 n = 113 | >6 n = 163 | ||
Sex (male) (%) | 204 (73.9%) | 85 (75.2%) | 119 (73%) | 0.680 |
Age (years) | 52.1 (10.5) | 51.2 (9.5) | 52.7 (11.1) | 0.260 |
BMI (kg/m2) | 28.7 (3.8) | 28.3 (4.2) | 28.9 (3.5) | 0.265 |
Waist circumference (cm) | 100.4 (12.5) | 102 (15.9) | 99.3 (9.8) | 0.137 |
Current or former smoker (%) | 169 (61.2%) | 72 (63.7%) | 97 (59.5%) | 0.481 |
Alcohol consumption (units/w) | 1.2 (2.7) | 1.5 (3.4) | 0.9 (2.0) | 0.069 |
Diet score (*) | 7.5 (3.3) | 7.3 (3.4) | 7.6 (3.3) | 0.440 |
Physical activity (hours/week) | 2.6 (3.0) | 2.5 (3.2) | 2.7 (2.9) | 0.558 |
HTA (%) | 94 (34.1%) | 40 (35.4%) | 54 (33.1%) | 0.696 |
DM (%) | 49 (17.8) | 18 (15.9%) | 31 (19%) | 0.509 |
Chronic renal disease (%) | 19 (6.9) | 6 (5.3%) | 13 (8%) | 0.390 |
Atherothrombotic cardiovascular disease | 75 (27.2%) | 30 (26.5%) | 45 (27.6%) | 0.846 |
Pancreatitis (%) | 2 (0.7%) | 0 (0%) | 2 (1.2%) | 0.515 |
Total cholesterol (mmol/L) * | 6.7 (1.8) | 6.4 (1.8) | 6.9 (1.8) | 0.029 |
HDL-c (mmol/L) * | 0.98 (0.32) | 1.0 (0.33) | 0.96 (0.31) | 0.269 |
LDL-c (mmol/L) * | 3.6 (1.5) | 3.7 (1.6) | 3.4 (1.4) | 0.272 |
non-HDL-c (mmol/L) * | 5.7 (1.8) | 5.4 (1.8) | 6.0 (1.8) | 0.018 |
TG (mmol/) | 5.3 (3.4 to 9.6) | 4.6 (3.0 to 6.9) | 5.8 (3.9 to 11.6) | <0.001 |
ApoB (mg/dL) | 1.2 (0.4) | 1.2 (0.4) | 1.2 (0.4) | 0.624 |
HbA1c (%) | 5.87 (0.71) | 5.88 (0.76) | 5.85 (0.67) | 0.764 |
Regression Coefficient (95% CI) | Standardized Coefficient | p | R2 | |
---|---|---|---|---|
Constant | 26.151 (0.28 to 52.02) | 0.048 | 0.131 | |
GRS | −3.08 (−6.80 to 0.64) | −0.70 | 0.104 | |
BMI (kg/m2) | −0.923 (−1.83 to −0.20) | −0.53 | 0.045 | |
GRS * BMI interaction | 0.15 (0.03 to 0.28) | 0.07 | 0.020 | |
Diet | −0.23 (−0.46 to 0.01) | −0.11 | 0.056 | |
DM | 2.02 (0.01 to 4.03) | 0.12 | 0.049 |
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Esteve-Luque, V.; Fanlo-Maresma, M.; Padró-Miquel, A.; Corbella, E.; Rivas-Regaira, M.; Pintó, X.; Candás-Estébanez, B. Polygenic Risk of Hypertriglyceridemia Is Modified by BMI. Int. J. Mol. Sci. 2022, 23, 9837. https://doi.org/10.3390/ijms23179837
Esteve-Luque V, Fanlo-Maresma M, Padró-Miquel A, Corbella E, Rivas-Regaira M, Pintó X, Candás-Estébanez B. Polygenic Risk of Hypertriglyceridemia Is Modified by BMI. International Journal of Molecular Sciences. 2022; 23(17):9837. https://doi.org/10.3390/ijms23179837
Chicago/Turabian StyleEsteve-Luque, Virginia, Marta Fanlo-Maresma, Ariadna Padró-Miquel, Emili Corbella, Maite Rivas-Regaira, Xavier Pintó, and Beatriz Candás-Estébanez. 2022. "Polygenic Risk of Hypertriglyceridemia Is Modified by BMI" International Journal of Molecular Sciences 23, no. 17: 9837. https://doi.org/10.3390/ijms23179837