Structural Significance of His73 in F-Actin Dynamics: Insights from Ab Initio Study
Abstract
:1. Introduction
2. Results and Discussion
2.1. The Structural Significance of His73 Methylation in F-Actin Dynamics
2.2. His73/Gly158 H-Bond Breaking Is Not Obligatory for Material Exchange in F-Actin Dynamics
3. Materials and Methods
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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PDB ID | States 1 | Ecomb 2 | EHis73 | EGly158 | Ebsse | Eb |
---|---|---|---|---|---|---|
1ATN | ATP/Y | −2,111,763.69 | −1,357,798.71 | −753,724.23 | 17.43 | −221.08 |
1Y64 | ATP/Y | −2,111,713.21 | −1,357,771.33 | −753,839.34 | 12.91 | −88.73 |
2A3Z | ATP/Y | −2,111,797.72 | −1,357,715.98 | −753,774.68 | 18.84 | −285.34 |
2FF6 | ATP/N | −2,007,737.54 | −1,253,918.49 | −753,814.92 | 7.35 | 3.19 |
2V52 | ATP/N | −2,007,744.46 | −1,253,947.10 | −753,829.20 | 7.41 | 38.86 |
3BUZ | ATP/N | −2,007,754.82 | −1,253,882.65 | −753,872.34 | 8.95 | 9.03 |
PDB ID | States 1 | Ecomb 2 | EHis73 | EGly158 | Ebsse | Eb |
---|---|---|---|---|---|---|
1NWK | ATP/Y | −2,111,727.89 | −1,357,765.61 | −753,810.78 | 12.18 | −137.92 |
1J6Z | ADP/Y | −2,111,661.74 | −1,357,758.88 | −753,828.18 | 6.61 | −67.39 |
3A5M | ATP/Y | −2,111,746.51 | −1,357,783.93 | −753,814.66 | 13.26 | −133.30 |
3A5L | ADP/Y | −2,111,751.50 | −1,357,775.95 | −753,597.98 | 24.34 | −349.71 |
2HF4 | ATP/N | −2,007,709.88 | −1,253,871.19 | −753,841.34 | 6.85 | 9.40 |
2HF3 | ADP/N | −2007699.82 | −1253870.48 | −753830.77 | 8.32 | 9.65 |
PDB ID | Nucleotide State | Methylation | Sources | Reference |
---|---|---|---|---|
1NWK | ATP | Yes | Oryctolagus | Dominguez, et al. 2001, 2003 [5,6] |
1J6Z | ADP | Yes | ||
3A5M | ATP | Yes | Dictyostelium | Murakami, et al. 2010 [8] |
3A5L | ADP | Yes | ||
2HF4 | ATP | No | Drosophila | Rould, et al. 2006 [7] |
2HF3 | ADP | No |
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Li, T.; Du, J.; Ren, M. Structural Significance of His73 in F-Actin Dynamics: Insights from Ab Initio Study. Int. J. Mol. Sci. 2022, 23, 10447. https://doi.org/10.3390/ijms231810447
Li T, Du J, Ren M. Structural Significance of His73 in F-Actin Dynamics: Insights from Ab Initio Study. International Journal of Molecular Sciences. 2022; 23(18):10447. https://doi.org/10.3390/ijms231810447
Chicago/Turabian StyleLi, Tong, Juan Du, and Mingfa Ren. 2022. "Structural Significance of His73 in F-Actin Dynamics: Insights from Ab Initio Study" International Journal of Molecular Sciences 23, no. 18: 10447. https://doi.org/10.3390/ijms231810447