Albumin as a Biomaterial and Therapeutic Agent in Regenerative Medicine
Abstract
:1. Introduction
2. Albumin as a Biomaterial
2.1. Coating
2.2. Anticoagulant Properties
2.3. Antibacterial Properties
2.4. Albumin as Cell Adhesion Protein
2.5. Scaffolds
2.5.1. Albumin-Only Scaffold
2.5.2. Albumin Hybrid Scaffolds and Hydrogels
3. Albumin as a Local Therapeutic Agent
3.1. Bioactive Sites on the Albumin Chain
3.2. Clinical Applications
3.3. Albumin and Blood-Derived Products
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Albumin Type | Molecular Weight | Structure | Main Characteristic | Production Method | Advantages | Limitations |
---|---|---|---|---|---|---|
Human serum albumin (HSA) | 66, 5–69 kDa 585 amino acids [4] |
|
|
|
| |
Bovine serum albumin (BSA) | 67 kDa 583 amino acids [4] |
|
|
|
|
|
Ovalbumin (OVA) | 47 kDa 385 amino acids [5] |
|
|
|
| Allergen [14] |
Lactalbumin | 14 kDa 122–123 amino acids [15] |
|
|
|
| Allergen [16] |
Plant albumin | 8–16 kDa [19,20] depending on the plant source |
|
|
| Allergen [23] | |
Recombinant albumin | Structurally equivalent to HSA [24] | Structurally equivalent to HSA [24] |
|
|
|
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Kuten Pella, O.; Hornyák, I.; Horváthy, D.; Fodor, E.; Nehrer, S.; Lacza, Z. Albumin as a Biomaterial and Therapeutic Agent in Regenerative Medicine. Int. J. Mol. Sci. 2022, 23, 10557. https://doi.org/10.3390/ijms231810557
Kuten Pella O, Hornyák I, Horváthy D, Fodor E, Nehrer S, Lacza Z. Albumin as a Biomaterial and Therapeutic Agent in Regenerative Medicine. International Journal of Molecular Sciences. 2022; 23(18):10557. https://doi.org/10.3390/ijms231810557
Chicago/Turabian StyleKuten Pella, Olga, István Hornyák, Dénes Horváthy, Eszter Fodor, Stefan Nehrer, and Zsombor Lacza. 2022. "Albumin as a Biomaterial and Therapeutic Agent in Regenerative Medicine" International Journal of Molecular Sciences 23, no. 18: 10557. https://doi.org/10.3390/ijms231810557