Molecular and Morphological Characteristics of the De-Obstructed Rat Urinary Bladder—An Update
Abstract
:1. Introduction
2. Results
2.1. mRNA Expression in Control, Obstructed, and De-Obstructed Bladders
2.2. Marked mRNA Differences between Obstructed, De-Obstructed, and Control Bladders
2.2.1. mRNAs for Structural Proteins
2.2.2. mRNAs for Proteins Involved in Metabolism
2.2.3. Neurotrophins
2.2.4. Connexins
2.2.5. Cell Surface Receptors
2.2.6. Apoptosis
2.2.7. Inflammation
2.3. Structural Differences between Obstructed, De-Obstructed, and Control Detrusors
3. Discussion
3.1. Structural Changes
3.2. Functional Changes
3.3. Structural and Functional Considerations, and Size of Dynamic Motor Units
4. Materials and Methods
4.1. Surgery
4.2. Electron Microscopy
4.3. Microarrays
4.4. Statistics
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Gene Symbol | Gene Description | Fold Change |
---|---|---|
Grem1 | gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis) | 17,13979 |
Trim59 | tripartite motif-containing 59 | 2,722014 |
Cdkn1c | cyclin-dependent kinase inhibitor 1C | 2,672856 |
Rspo3 | R-spondin 3 homolog (Xenopus laevis) | 2,502077 |
RGD1564327 | similar to integrin alpha 8 | 2,322538 |
Cthrc1 | collagen triple helix repeat containing 1 | 2,212791 |
Eda2r | ectodysplasin A2 receptor | 2,182682 |
Fxyd6 | FXYD domain-containing ion transport regulator 6 | 2,136691 |
Adora2b | adenosine A2B receptor | 2,105719 |
Edn1 | endothelin 1 | 2,099241 |
Acadsb | acyl-Coenzyme A dehydrogenase, short/branched chain | 2,090642 |
Angptl1 | angiopoietin-like 1 | 2,064316 |
Abcb1b | ATP-binding cassette, sub-family B (MDR/TAP), member 1B | 2,057768 |
Phlda1 | pleckstrin homology-like domain, family A, member 1 | 0,494031 |
Cadps | Ca++-dependent secretion activator | 0,49359 |
Col1a1 | collagen type I alpha 1 | 0,492934 |
Nrk | Nik related kinase | 0,491153 |
Mfap2 | microfibrillar-associated protein 2 | 0,469284 |
Nrg1 | neuregulin 1 | 0,466933 |
Itm2a | integral membrane protein 2A | 0,450881 |
Slc30a10 | solute carrier family 30, member 10 | 0,445451 |
Hhip | Hedgehog-interacting protein | 0,437063 |
Ahrr | aryl-hydrocarbon receptor repressor | 0,43424 |
Krt20 | keratin 20 | 0,415004 |
Fam111a | family with sequence similarity 111, member A | 0,403881 |
Igfbp3 | insulin-like growth factor binding protein 3 | 0,322226 |
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Uvelius, B.; Andersson, K.-E. Molecular and Morphological Characteristics of the De-Obstructed Rat Urinary Bladder—An Update. Int. J. Mol. Sci. 2022, 23, 11330. https://doi.org/10.3390/ijms231911330
Uvelius B, Andersson K-E. Molecular and Morphological Characteristics of the De-Obstructed Rat Urinary Bladder—An Update. International Journal of Molecular Sciences. 2022; 23(19):11330. https://doi.org/10.3390/ijms231911330
Chicago/Turabian StyleUvelius, Bengt, and Karl-Erik Andersson. 2022. "Molecular and Morphological Characteristics of the De-Obstructed Rat Urinary Bladder—An Update" International Journal of Molecular Sciences 23, no. 19: 11330. https://doi.org/10.3390/ijms231911330